Document Detail


Oxytocin in the NTS. A new modulator of cardiovascular control during exercise.
MedLine Citation:
PMID:  11458679     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The role of brain stem oxytocinergic projections in the modulation of heart rate control during exercise is discussed on the basis of both changes in endogenous peptide content and heart rate changes observed during exercise. Running on a treadmill caused an increase in oxytocin content in dorsal/ventral brain stem areas and spinal cord, specifically in trained rats. Trained rats pretreated with a specific oxytocin receptor antagonist into the dorsal brain stem area (corresponding to the nucleus tractus solitarii and dorsal motor nucleus of the vagus, or NTS/DMV) showed a significant potentiation of exercise tachycardia with no change in the blood pressure response. The same treatment in sedentary rats was without effect. On the other hand, administration of exogenous oxytocin into this area caused significant blunting of exercise tachycardia in both groups, with no change in the pressure response. It is proposed that long-descending oxytocinergic pathways from the hypothalamus to the NTS/DMV area serve as a link between the two main neural controllers of the circulation--that is, the central command and feedback control mechanisms driven by the peripheral receptor signals. Our results strongly suggest that oxytocinergic input to NTS/DMV, by restraining the tachycardic response of trained individuals, contributes to the smaller response observed after training, without compromising cardiac output adjustment and the circulatory demand during exercise.
Authors:
L C Michelini
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  940     ISSN:  0077-8923     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-07-18     Completed Date:  2001-08-09     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  206-20     Citation Subset:  IM    
Affiliation:
Department of Physiology and Biophysics, ICB, University of São Paulo, Av. Prof. Lineu Prestes, 1524, 05508-900, São Paulo, SP, Brasil. michelin@usp.br
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain Stem / physiology
Cardiovascular Physiological Phenomena*
Motor Activity / physiology*
Oxytocin / physiology*
Solitary Nucleus / physiology*
Synaptic Transmission / physiology
Chemical
Reg. No./Substance:
50-56-6/Oxytocin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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