Document Detail

Oxytocin has dose-dependent developmental effects on pair-bonding and alloparental care in female prairie voles.
MedLine Citation:
PMID:  17553502     Owner:  NLM     Status:  MEDLINE    
The present study examines the developmental consequences of neonatal exposure to oxytocin on adult social behaviors in female prairie voles (Microtus ochrogaster). Female neonates were injected within 24 h of birth with isotonic saline or one of four dosages of oxytocin (OT). As adults, females were tested in an elevated plus-maze paradigm (a measure of anxiety and exploratory behavior), and for alloparental behavior and partner preferences. At 2 mg/kg OT, females took longer to approach pups, but were the only group to form a statistically significant within-group partner preference. At 4 mg/kg OT, females retrieved pups significantly more frequently but no longer displayed a partner preference; while females treated developmentally with 8 mg/kg spent significantly more time in side-to-side contact with a male stranger than any other treatment group. OT may have broad developmental consequences, but these effects are not linear and may both increase and decrease the propensity to display behaviors such as pair-bonding.
Karen L Bales; Julie A van Westerhuyzen; Antoniah D Lewis-Reese; Nathaniel D Grotte; Jalene A Lanter; C Sue Carter
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2007-05-10
Journal Detail:
Title:  Hormones and behavior     Volume:  52     ISSN:  0018-506X     ISO Abbreviation:  Horm Behav     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-07-30     Completed Date:  2007-11-07     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  0217764     Medline TA:  Horm Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  274-9     Citation Subset:  IM    
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MeSH Terms
Animals, Newborn
Arvicolinae / growth & development*,  physiology*
Dose-Response Relationship, Drug
Maze Learning / drug effects
Nesting Behavior / drug effects*
Oxytocin / pharmacology*
Pair Bond*
Grant Support
F32 HD008702/HD/NICHD NIH HHS; F32 HD008702-01/HD/NICHD NIH HHS; F32 HD008702-02/HD/NICHD NIH HHS; F32 HD008702-03/HD/NICHD NIH HHS; F32 HD08702/HD/NICHD NIH HHS; P01 HD038490/HD/NICHD NIH HHS; P01 HD038490-01/HD/NICHD NIH HHS; P01 HD038490-02/HD/NICHD NIH HHS; P01 HD038490-03/HD/NICHD NIH HHS; P01 HD038490-04/HD/NICHD NIH HHS; P01 HD038490-05/HD/NICHD NIH HHS; P01 HD38490/HD/NICHD NIH HHS; R01 073022//PHS HHS; R01 MH073022/MH/NIMH NIH HHS; R01 MH073022-02/MH/NIMH NIH HHS; R01 MH073022-03/MH/NIMH NIH HHS
Reg. No./Substance:

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