Document Detail

Oxytocin and fetal membranes in preterm labor: current concepts and clinical implication.
MedLine Citation:
PMID:  12857435     Owner:  NLM     Status:  MEDLINE    
Preterm birth is associated with up to 90% of perinatal deaths. In spite of numerous clinical and preclinical research programs, its incidence has not changed throughout the past decade. An observation that the oxytocin antagonist atosiban delays preterm labor and is significantly more potent than vasopressin(1a) receptors gave rise to research on the role of vasopressin blockade in tocolysis and vasopressin itself in preterm labor. Successful tocolysis allows the introduction of intrauterine steroid treatment of the fetus, which reduces the chance of developing infant respiratory distress syndrome and intracranial hemorrhage. Fetal membranes, decidua and placenta are considered a possible site of initiation of parturition, both term and preterm. Research on the biology of these tissues may shed new light on current concepts of the pathophysiology of preterm labor. We here present a short review on the role of oxytocin, oxytocin receptor blockade and fetal membranes in preterm labor.
T Laudanski; P Pierzynski
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology     Volume:  17     ISSN:  0951-3590     ISO Abbreviation:  Gynecol. Endocrinol.     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-07-14     Completed Date:  2003-10-17     Revised Date:  2008-09-03    
Medline Journal Info:
Nlm Unique ID:  8807913     Medline TA:  Gynecol Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  261-7     Citation Subset:  IM    
Department of Pathophysiology of Pregnancy, Medical University of Bialystok, M.C. Sklodowskiej 24a, 15-276 Bialystok, Poland.
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MeSH Terms
Extraembryonic Membranes*
Indoles / therapeutic use
Obstetric Labor, Premature* / prevention & control
Oxytocin* / antagonists & inhibitors
Pyrrolidines / therapeutic use
Receptors, Oxytocin / antagonists & inhibitors
Vasotocin / analogs & derivatives*,  therapeutic use
Reg. No./Substance:
0/Indoles; 0/Pyrrolidines; 0/Receptors, Oxytocin; 150375-75-0/relcovaptan; 50-56-6/Oxytocin; 9034-50-8/Vasotocin; 90779-69-4/atosiban

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