Document Detail

Oxytocin does not directly affect vascular tone in vessels from nonpregnant and pregnant rats.
MedLine Citation:
PMID:  11893555     Owner:  NLM     Status:  MEDLINE    
Recent evidence suggests oxytocin (OT) may regulate vascular tone. OT and its receptor (OTR) have been identified in the rat heart and great vessels. Expression of OT and OTR is increased in some tissues during pregnancy. We hypothesized that the OT/OTR system may be a physiological regulator of vascular tone and mediate the decreased vascular resistance noted during pregnancy. Using a wire myograph system, we measured changes in vascular tone in response to OT in small mesenteric arteries, uterine arcuate arteries, and thoracic aorta from nonpregnant and pregnant rats. Additionally, we used reverse transcriptase-polymerase chain reaction (RT-PCR) to measure mRNA for OTR in these vascular tissues. Although OTR mRNA was identified by RT-PCR, OT did not elicit a vasodilatory effect in any of the vessels studied. High concentrations of OT (>10(-8) M) caused vasoconstriction that was eliminated by a specific vasopressin V(1a) receptor antagonist. Although it may have an indirect effect in regulation of peripheral resistance, we conclude that OT is unlikely to play a direct role in the physiological regulation of vascular tone.
M E Miller; S T Davidge; B F Mitchell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  282     ISSN:  0363-6135     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-03-14     Completed Date:  2002-05-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  H1223-8     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University of Alberta, Edmonton, Alberta, Canada T6G 2S2.
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MeSH Terms
Aorta, Abdominal / drug effects,  physiology
Arteries / drug effects,  physiology
Gene Expression Regulation / drug effects
Mesenteric Arteries / drug effects,  physiology
Methacholine Chloride / pharmacology
Muscle Tonus / physiology*
Muscle, Smooth, Vascular / drug effects,  physiology*
Oxytocin / genetics,  pharmacology*
Phenylephrine / pharmacology
Pregnancy, Animal / physiology*
Rats, Sprague-Dawley
Receptors, Oxytocin / genetics,  physiology
Reverse Transcriptase Polymerase Chain Reaction
Uterus / blood supply,  drug effects,  physiology*
Vasoconstriction / drug effects,  physiology
Reg. No./Substance:
0/Receptors, Oxytocin; 50-56-6/Oxytocin; 59-42-7/Phenylephrine; 62-51-1/Methacholine Chloride

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