Document Detail


Oxytocin as feeding inhibitor: maintaining homeostasis in consummatory behavior.
MedLine Citation:
PMID:  20595062     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Initial studies showed that the anorexigenic peptide oxytocin (OT) regulates gastric motility, responds to stomach distention and to elevated osmolality, and blocks consumption of toxic foods. Most recently, it has been proposed to act as a mediator of general and carbohydrate-specific satiety and regulator of body weight. In the current review, we discuss the function of OT as a homeostatic inhibitor of consumption, capable of mitigating multiple aspects of ingestive behavior and energy metabolism.
Authors:
Pawel K Olszewski; Anica Klockars; Helgi B Schiöth; Allen S Levine
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-06-02
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  97     ISSN:  1873-5177     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-11     Completed Date:  2011-09-15     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  47-54     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Affiliation:
Minnesota Obesity Center, Department of Food Science and Nutrition, University of Minnesota, St. Paul, MN 55108, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anorexia / chemically induced,  physiopathology
Consummatory Behavior / drug effects,  physiology*
Energy Metabolism / drug effects,  physiology
Feeding Behavior / drug effects,  physiology*
Homeostasis / drug effects,  physiology*
Humans
Obesity / physiopathology,  prevention & control
Oxytocin / pharmacology,  physiology*
Grant Support
ID/Acronym/Agency:
P30 DK050456-12/DK/NIDDK NIH HHS; R01 DA021280-03/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
50-56-6/Oxytocin
Comments/Corrections

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