Document Detail

Oxytocin administration, instillation-to-abortion time, and morbidity associated with saline instillation.
MedLine Citation:
PMID:  1115183     Owner:  NLM     Status:  MEDLINE    
Among 4,069 healthy gravidas undergoing saline abortion, patients administered intravenous oxytocin had a significantly shorter instillation-to-abortion time (median, 25.5 hours) than did patients not administered oxytocin (median 33.3 hours). The instillation-to-abortion time was independent of the rate of oxytocin administration, which ranged from 1 to 4 U. per hour (17 to 67 mU. per minute), but was associated with the time at which oxytocin infusion was begun. When oxytocin infusion was started within eight hours after instillation, a shortened time from instillation to abortion was observed. Although oxytocin augmentation may result in a lower proportion of patients being exposed to the risk of infection associated with prolonged intervals from instillation to abortion, this potential advantage appears counterbalanced by an increased incidence of clinical consumptive coagulopathy associated with instillation-to-abortion intervals of less than 24 hours.
G S Berger; D A Edelman; T D Kerenyi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  121     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1975 Apr 
Date Detail:
Created Date:  1975-05-21     Completed Date:  1975-05-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  941-6     Citation Subset:  AIM; IM    
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MeSH Terms
Abortion, Induced* / adverse effects
Disseminated Intravascular Coagulation / etiology
Hypertonic Solutions
Infection / etiology
Oxytocin / adverse effects,  therapeutic use*
Sodium Chloride / adverse effects,  therapeutic use*
Time Factors
Reg. No./Substance:
0/Hypertonic Solutions; 50-56-6/Oxytocin; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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