Document Detail

Oxytocin administration attenuates atherosclerosis and inflammation in Watanabe Heritable Hyperlipidemic rabbits.
MedLine Citation:
PMID:  22998949     Owner:  NLM     Status:  MEDLINE    
Oxytocin (OT) is a neurohypophyseal peptide traditionally associated with female reproductive functioning, and more recently with prosocial behavior. OT and its receptor are also expressed in the heart and vascular tissue and play a role in cardiovascular homeostasis. In vitro, it has been demonstrated that OT decreases NADPH-dependent superoxide production and pro-inflammatory cytokine release from vascular endothelial cells and macrophages, suggesting that OT may attenuate pathophysiological processes involved with atherosclerotic lesion formation. The present study sought to determine the effect of chronic exogenous OT administration on inflammation and atherosclerosis in an animal model of dyslipidemia and atherosclerosis, the Watanabe Heritable Hyperlipidemic (WHHL) rabbit. Twenty-two, 3-month-old WHHLs were surgically implanted with osmotic mini-pumps containing OT (n=11) or vehicle (n=11), and then were individually housed for the entire study. Blood and 24-h urine samples were taken at baseline and after 8 (midpoint) and 16 (endpoint) weeks of treatment. At endpoint, the aortas and visceral fat samples were dissected and stored for analyses. There were no group differences in body weight, serum lipids, plasma/urinary measures of oxidative stress, plasma cortisol or urinary catecholamines over the 16-week treatment. OT-treated animals exhibited significantly lower plasma C-reactive protein levels at midpoint and endpoint and developed significantly less atherosclerosis in the thoracic aorta relative to vehicle control animals at endpoint (p<0.05). Cytokine gene expression from visceral adipose tissue samples suggested that there was a decrease in adipose tissue inflammation in the OT-treated group compared to the vehicle control group, however these differences were not statistically significant. These results suggest that chronic peripheral OT administration can inhibit inflammation and atherosclerotic lesion development.
Angela Szeto; Maria A Rossetti; Armando J Mendez; Crystal M Noller; Edward E Herderick; Julie A Gonzales; Neil Schneiderman; Philip M McCabe
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-09-19
Journal Detail:
Title:  Psychoneuroendocrinology     Volume:  38     ISSN:  1873-3360     ISO Abbreviation:  Psychoneuroendocrinology     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-15     Completed Date:  2013-10-31     Revised Date:  2014-05-08    
Medline Journal Info:
Nlm Unique ID:  7612148     Medline TA:  Psychoneuroendocrinology     Country:  England    
Other Details:
Languages:  eng     Pagination:  685-93     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
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MeSH Terms
Adipose Tissue / drug effects,  metabolism
Atherosclerosis / complications,  drug therapy*,  metabolism,  pathology
Biological Markers / analysis,  metabolism
Blood Glucose / analysis,  metabolism
Disease Models, Animal
Inflammation / complications,  drug therapy*,  metabolism,  pathology
Infusion Pumps
Insulin / blood
Lipids / blood
Oxytocin / administration & dosage,  pharmacology*
Stress, Physiological / drug effects,  genetics
Validation Studies as Topic
Grant Support
Reg. No./Substance:
0/Biological Markers; 0/Blood Glucose; 0/Insulin; 0/Lipids; 50-56-6/Oxytocin

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