Document Detail


Oxytocin modulates amygdala, insula, and inferior frontal gyrus responses to infant crying: a randomized controlled trial.
MedLine Citation:
PMID:  21470595     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Oxytocin facilitates parental caregiving and mother-infant bonding and might be involved in responses to infant crying. Infant crying provides information about the physical status and mood of the infant and elicits parental proximity and caregiving. Oxytocin might modulate the activation of brain structures involved in the perception of cry sounds-specifically the insula, the amygdala, and the thalamocingulate circuit-and thereby affect responsiveness to infant crying.
METHOD: In a randomized controlled trial we investigated the influence of intranasally administered oxytocin on neural responses to infant crying with functional magnetic resonance imaging. Blood oxygenation level-dependent responses to infant crying were measured in 21 women who were administered oxytocin and 21 women who were administered a placebo.
RESULTS: Induced oxytocin levels reduced, experimentally, activation in the amygdala and increased activation in the insula and inferior frontal gyrus pars triangularis.
CONCLUSIONS: Our findings suggest that oxytocin promotes responsiveness to infant crying by reducing activation in the neural circuitry for anxiety and aversion and increasing activation in regions involved in empathy.
Authors:
Madelon M E Riem; Marian J Bakermans-Kranenburg; Suzanne Pieper; Mattie Tops; Maarten A S Boksem; Robert R J M Vermeiren; Marinus H van Ijzendoorn; Serge A R B Rombouts
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Twin Study     Date:  2011-04-05
Journal Detail:
Title:  Biological psychiatry     Volume:  70     ISSN:  1873-2402     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-12     Completed Date:  2011-11-18     Revised Date:  2012-04-24    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  291-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
Affiliation:
Centre for Child and Family Studies, Leiden University Medical Center, Leiden University, Leiden, the Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Adult
Amygdala / drug effects*,  physiology
Auditory Perception / physiology
Cerebral Cortex / drug effects*,  physiology
Crying / physiology*
Empathy
Female
Frontal Lobe / drug effects*,  physiology
Humans
Middle Aged
Neurons / drug effects*,  physiology
Oxytocin / pharmacology*
Chemical
Reg. No./Substance:
50-56-6/Oxytocin
Comments/Corrections
Erratum In:
Biol Psychiatry. 2012 Apr 1;71(7):660

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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