Document Detail


Oxysterols in heart failure.
MedLine Citation:
PMID:  19656059     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Oxysterols are biologically active molecules that result from the oxidation of cholesterol. Several oxysterols are found in macrophages and macrophage-derived 'foam cells' in atherosclerotic tissue. Lipophilic oxysterols penetrate cell membranes and, therefore, their concentrations can reach harmful levels in endothelial and smooth muscle cells located in close proximity to the atherosclerotic plaques or inflammatory zones. New findings suggest that the effects of oxysterols on cardiomyocytes can lead to cell hypertrophy and death. This may make oxysterols one of the major factors precipitating morbidity in atherosclerosis-induced cardiac diseases and inflammation-induced heart complications. The pathological actions of oxysterols on muscle cells were shown to depend on dysfunctional Ca(2+) signaling; however, the mechanisms of the effects remain to be elucidated. Understanding the effects of oxysterols could lead to therapies that modulate malfunction of cardiomyocytes. This review discusses the experimental findings and the relevance of oxysterols to heart failure, and suggests strategies for important future investigations.
Authors:
Valeriy Lukyanenko; Yevgeniya Lukyanenko
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Future cardiology     Volume:  5     ISSN:  1744-8298     ISO Abbreviation:  Future Cardiol     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-08-06     Completed Date:  2009-10-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101239345     Medline TA:  Future Cardiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  343-54     Citation Subset:  IM    
Affiliation:
Medical Biotechnology Center, University of Maryland Biotechnology Institute, Baltimore, MD 21201, USA. lukyanen@umbi.umd.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis
Arteriosclerosis / metabolism
Calcium / metabolism
Cholesterol / metabolism*
Heart Failure / metabolism*
Humans
Macrophages / metabolism
Muscle, Smooth / pathology
Myocardium / metabolism
Myocytes, Cardiac / metabolism
Oxidation-Reduction
Chemical
Reg. No./Substance:
57-88-5/Cholesterol; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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