| Oxysterols as non-genomic regulators of cholesterol homeostasis. | |
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MedLine Citation:
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PMID: 22244444 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Tight regulation of cellular and plasma cholesterol is crucial to proper cellular functioning because excess free cholesterol is toxic to cells and is associated with atherosclerosis and heart disease. Cellular cholesterol homeostasis is regulated by enzymatically formed oxygenated cholesterol derivatives termed oxysterols. Although the effects of oxysterols on transcriptional pathways are well described, the non-transcriptional mechanisms through which oxysterols acutely modulate cellular cholesterol levels are less well understood. We present emerging evidence suggesting that the membrane biophysical properties of oxysterols underlie their acute cholesterol-regulatory functions and discuss the relevance of these acute effects to cholesterol overload in physiological and pathophysiological states. |
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Authors:
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Agata A Bielska; Paul Schlesinger; Douglas F Covey; Daniel S Ory |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-11 |
Journal Detail:
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Title: Trends in endocrinology and metabolism: TEM Volume: - ISSN: 1879-3061 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9001516 Medline TA: Trends Endocrinol Metab Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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Diabetic Cardiovascular Disease Center, Washington University School of Medicine, St Louis, MO 63110, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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