Document Detail

Oxygenation response to a recruitment maneuver during supine and prone positions in an oleic acid-induced lung injury model.
MedLine Citation:
PMID:  10852772     Owner:  NLM     Status:  MEDLINE    
Prone position and recruitment maneuvers (RM) are proposed as adjuncts to mechanical ventilation to open up the lung and keep it open. We studied the oxygenation response to a RM (composed of a 30-s sustained inflation at 60 cm H(2)O airway pressure) performed in prone and supine positions in dogs after oleic acid- induced lung injury using an inspired O(2) fraction of 0.60. In one group (n = 6) first supine then prone positions were examined after a RM at 8 cm H(2)O and 15 cm H(2)O of positive end-expiratory pressure (PEEP). In the second group (n = 6) the sequence of positions was reversed. Prone positioning after supine position always improved oxygenation, whereas the decrement in Pa(O(2)) was relatively small when dogs were returned to the supine position. Oxygenation improved in both groups after a RM, and the improvement was sustained (after 15 min) in the prone position at 8 cm H(2)O of PEEP, but 15 cm H(2)O of PEEP was required in supine position. Our results suggest that a RM improves oxygenation more effectively with a decreased PEEP requirement for the preservation of the oxygenation response in prone compared with supine position.
N Cakar; T V der Kloot; M Youngblood; A Adams; A Nahum
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  161     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-08-01     Completed Date:  2000-08-01     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1949-56     Citation Subset:  AIM; IM    
Department of Anesthesiology and Intensive Care, University of Istanbul, Istanbul Medical Faculty Capa, Istanbul, Turkey.
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MeSH Terms
Lung / physiopathology
Lung Volume Measurements
Oleic Acid
Oxygen / physiology*
Positive-Pressure Respiration*
Prone Position / physiology*
Pulmonary Gas Exchange / physiology
Respiratory Distress Syndrome, Adult / chemically induced,  physiopathology*
Supine Position / physiology*
Grant Support
Reg. No./Substance:
112-80-1/Oleic Acid; 7782-44-7/Oxygen

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