| Oxygenation of phosphatidylcholine by human polymorphonuclear leukocyte 15-lipoxygenase. | |
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MedLine Citation:
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PMID: 3927906 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A cell-free human polymorphonuclear leukocyte preparation containing both 15- and 5-lipoxygenase activities was found to oxygenate phosphatidylcholine at carbon-15 of the arachidonic acid moiety. No oxygenation at carbon-5 was found. Under similar incubation conditions, soybean and rabbit reticulocyte 15-lipoxygenases also oxygenated phosphatidylcholine, whereas rat basophilic leukemia cell 5-lipoxygenase, rabbit platelet 12-lipoxygenase and rat liver cytochrome P-450 preparations did not. Our results suggest that the oxygenation of phospholipids may be a unique property of the 15-lipoxygenases. |
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Authors:
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G Jung; D C Yang; A Nakao |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 130 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 1985 Jul |
Date Detail:
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Created Date: 1985-09-16 Completed Date: 1985-09-16 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 559-66 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arachidonate Lipoxygenases Arachidonic Acid Arachidonic Acids / metabolism Basophils / enzymology Blood Platelets / enzymology Cell-Free System Cytochrome P-450 Enzyme System / metabolism Humans Lipoxygenase / metabolism* Liver / enzymology Neutrophils / enzymology* Oxygen Phosphatidylcholines / metabolism* Rabbits Rats Species Specificity Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Arachidonic Acids; 0/Phosphatidylcholines; 506-32-1/Arachidonic Acid; 7782-44-7/Oxygen; 9035-51-2/Cytochrome P-450 Enzyme System; EC 1.13.11.-/Arachidonate Lipoxygenases; EC 1.13.11.12/Lipoxygenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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