| Oxygenation of the newborn: a molecular approach. | |
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MedLine Citation:
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PMID: 22940621 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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In this review oxygenation and hyperoxic injury of newborn infants are described through molecular and genetic levels. Protection and repair mechanisms that may be important for a new understanding of oxidative stress in the newborn are discussed. The research summarized in this article represents a basis for the reduced oxygen supplementation and oxidative load of newborn babies, especially since the turn of the century. The mechanisms discussed may also contribute to an understanding of why hyperoxic resuscitation of the newborn may damage DNA and affect its repair, thus increasing the risk that it may be carcinogenic. Today, term babies should be resuscitated with air rather than 100% oxygen and very and extremely low birth weight infants in need of stabilization or resuscitation at birth should be administered initially 21-30% oxygen and the level should be titrated according to the response, preferably measured by pulse oximetry. In the postnatal period the oxygen saturation should be targeted low <95%; however, saturations between 85 and 89% seem to increase mortality. The optimal oxygen saturation target for these infants postnatally is still unknown. |
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Authors:
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Ola Didrik Saugstad; Yngve Sejersted; Rønnaug Solberg; Embjørg J Wollen; Magnar Bjørås |
Publication Detail:
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Type: Journal Article Date: 2012-06-01 |
Journal Detail:
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Title: Neonatology Volume: 101 ISSN: 1661-7819 ISO Abbreviation: Neonatology Publication Date: 2012 |
Date Detail:
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Created Date: 2012-09-03 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101286577 Medline TA: Neonatology Country: Switzerland |
Other Details:
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Languages: eng Pagination: 315-25 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 S. Karger AG, Basel. |
Affiliation:
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Department of Pediatric Research, Women and Children's Division, Oslo University Hospital, University of Oslo, Oslo, Norway. |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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