Document Detail

Oxygenation equilibration time after alteration of inspired oxygen in critically ill patients.
MedLine Citation:
PMID:  20207275     Owner:  NLM     Status:  MEDLINE    
To determine the time required for arterial oxygen partial pressure (Pao(2)) equilibration after a change in fractional inspired oxygen (Fio(2)) in intensive care unit (ICU) patients, a prospective study in a 7-bed university ICU was performed. Forty adult patients were examined using sequential arterial blood gas measurements after a .3 alteration in Fio(2). The Pao(2) value measured at 30 minutes after a step change in Fio(2) in both periods was accepted as representative of the equilibrium value for Pao(2). The mean equilibration time was 8.26+/-5.6 minutes and 4.5+/-2.65 minutes for increases and decreases in Pao(2), respectively (P=.003). The constant k values were .44 +/- .31 minutes and .72 +/- .7 minutes for increases and decreases in Pao(2), respectively. There was no significant difference between the increase and the decrease of 90% oxygenation times in the 2 groups (P=.150 and P=.446, respectively). The study confirms that a period of less than 10 minutes is adequate for 90% of the equilibration of Pao(2) to occur after an Fio(2) change in ICU patients.
George Fildissis; Theofanis Katostaras; Athanassios Moles; Andreas Katsaros; Paylos Myrianthefs; Hero Brokalaki; K Tsoumakas; George Baltopoulos
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Publication Detail:
Type:  Journal Article     Date:  2009-08-13
Journal Detail:
Title:  Heart & lung : the journal of critical care     Volume:  39     ISSN:  1527-3288     ISO Abbreviation:  Heart Lung     Publication Date:    2010 Mar-Apr
Date Detail:
Created Date:  2010-03-08     Completed Date:  2010-06-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0330057     Medline TA:  Heart Lung     Country:  United States    
Other Details:
Languages:  eng     Pagination:  147-52     Citation Subset:  AIM; IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
National and Kapodistrian University of Athens, ICU, KAT General Hospital, Nikis 2, 14561, Kifissia, Athens, Greece.
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MeSH Terms
Aged, 80 and over
Blood Gas Analysis
Critical Illness*
Intensive Care Units
Least-Squares Analysis
Middle Aged
Oxygen / administration & dosage,  blood*
Oxygen Inhalation Therapy
Prospective Studies
Time Factors
Reg. No./Substance:

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