Document Detail

Oxygen utilization, carbon dioxide elimination and ventilation during recovery from supine bicycle exercise 6 to 8 weeks after acute myocardial infarction.
MedLine Citation:
PMID:  2035436     Owner:  NLM     Status:  MEDLINE    
The pattern of oxygen (O2) consumption (VO2), carbon dioxide (CO2) production (VCO2), ventilatory and metabolic responses during and in recovery from supine bicycle exercise was examined in 18 patients with recent myocardial infarction. An increase in VO2 with increasing work load was accomplished by proportional increases in both cardiac output and the arteriovenous O2 difference. During recovery, however, the arteriovenous O2 difference rapidly decreased below levels at rest, whereas VO2 and cardiac output remained elevated, indicating that VO2 during recovery further depended on relatively high cardiac output. The ratio of VCO2 to VO2 further increased after exercise, suggesting that such cardiac output contributed to the remaining high CO2 flow to the lung and therefore enhanced ventilation. Increased arterial catecholamines during exercise remained elevated for the first 5 minutes of recovery. Arterial lactate during this period continued to increase and resulted in profound metabolic acidosis, causing alveolar hyperventilation after exercise. These results suggest that during recovery from exercise, cardiopulmonary responses remain enhanced because of continuing high cardiac output, resulting in subsequent high CO2 flow to the lung and metabolic acidosis, and that this may be associated with profound fatigue or dyspnea after exercise.
T Sumimoto; T Sugiura; M Takeuchi; F Yuasa; T Hasegawa; S Nakamura; T Iwasaka; M Inada
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of cardiology     Volume:  67     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1991 Jun 
Date Detail:
Created Date:  1991-06-21     Completed Date:  1991-06-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1170-4     Citation Subset:  AIM; IM; S    
Second Department of Internal Medicine, Kansai Medical University, Osaka, Japan.
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MeSH Terms
Acidosis, Lactic / etiology
Blood Gas Analysis
Cardiac Output / physiology*
Exercise / physiology*
Exercise Test
Middle Aged
Myocardial Infarction / physiopathology*
Oxygen Consumption / physiology
Pulmonary Gas Exchange / physiology*
Time Factors

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