Document Detail

Oxygen uptake kinetics during and after exercise are useful markers of coronary artery disease in patients with exercise electrocardiography suggesting myocardial ischemia.
MedLine Citation:
PMID:  19661720     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The aim of the current study was to determine if the slowed exercise oxygen uptake (VO(2)) kinetics, which is developed by myocardial ischemia, would be accompanied by delayed recovery VO(2) kinetics in patients with coronary artery disease (CAD). METHODS AND RESULTS: Thirty-seven patients with significant ST depression during treadmill exercise underwent cardiopulmonary exercise testing with cycle ergometer. Measurements performed are the ratios of change in increase in oxygen (O(2)) uptake relative to increase in work rate (DeltaVO(2)/DeltaWR) across anaerobic threshold (AT) and 1 mm ST depression point (ST-dep), the time constants of VO(2) during recovery (T(1/2) VO(2)), stress radio-isotope scintigraphy and coronary angiography. Patients were divided into CAD positive (CAD+) and CAD negative (CAD-) groups, based on coronary angiography. In CAD+, DeltaVO(2)/DeltaWR decreased above AT and ST-dep, in contrast to CAD- patients. The T(1/2) VO(2) in CAD+ (103.1 +/-13.0 s) was greater than that of CAD- (76.5 +/-8.7 s) and showed negative correlations to the ratios of DeltaVO(2)/DeltaWR across AT and ST-dep. These parameters improved in the patients who underwent coronary bypass surgery. CONCLUSIONS: Exercise and recovery VO(2) kinetics were slowed when myocardial ischemia was provoked by exercise. Measurement of exercise and recovery VO(2) kinetics improve the accuracy of the exercise electrocardiogram diagnosis of CAD.
Akihiko Tajima; Haruki Itoh; Naohiko Osada; Kazuto Omiya; Tomoko Maeda; Nobuyuki Ohkoshi; Tokuhiro Kawara; Tadanori Aizawa; Karlman Wasserman
Publication Detail:
Type:  Journal Article     Date:  2009-08-07
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  73     ISSN:  1347-4820     ISO Abbreviation:  Circ. J.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-09-25     Completed Date:  2009-12-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1864-70     Citation Subset:  IM    
The Cardiovascular Institute, Graduate School of Health Sciences Tokyo Medical and Dental University, Japan.
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MeSH Terms
Anaerobic Threshold
Biological Markers / metabolism
Coronary Angiography
Coronary Artery Bypass
Coronary Stenosis / complications,  diagnosis*,  metabolism,  surgery
Exercise Test*
Middle Aged
Myocardial Ischemia / diagnosis*,  etiology,  metabolism
Myocardial Perfusion Imaging
Oxygen / metabolism*
Oxygen Consumption*
Predictive Value of Tests
Pulmonary Gas Exchange*
Recovery of Function
Severity of Illness Index
Treatment Outcome
Reg. No./Substance:
0/Biological Markers; 7782-44-7/Oxygen
Comment In:
Circ J. 2009 Oct;73(10):1795-6   [PMID:  19779272 ]

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