| Oxygen uptake efficiency slope correlates with brain natriuretic peptide in patients with heart failure. | |
| | |
MedLine Citation:
|
PMID: 20690091 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Cardiopulmonary exercise testing is a well-established tool for clinical and prognostic assessment of patients with chronic heart failure (CHF). Recently, a new parameter of this examination--oxygen uptake efficiency slope (OUES)--has been described and proposed as a new prognostic factor in patients with CHF. Brain natriuretic peptide (BNP) is an established prognostic factor in CHF. The purpose of the study was to assess OUES in patients with CHF in relation to other cardiopulmonary parameters and BNP levels. METHODS: The study group consisted of 42 patients with CHF and left ventricular ejection fraction (LVEF) < 45% (mean age 50.2 +/- 9.3 years, mean ejection fraction 26.1 +/- 8.1% and NYHA functional class - 2.5 +/- 0.8) and eight healthy controls (age 43.6 +/- 14.7 years). Coronary artery disease was diagnosed in 16 patients (38%). All underwent maximal cardiopulmonary exercise treadmill test. BNP level was measured using Abbott AxSYM Immunoassay system. RESULTS: There were significant (p < 0.001) differences between the patients and controls in BNP levels (350 +/- 520 vs 14 +/- 19 pg/mL), OUES (1.7 +/- 0.4 vs 2.7 +/- 0.5), peak VO(2) (17.1 +/- +/- 5.1 vs 36.9 +/- 4.9 mL/kg/min), O(2) pulse (10.9 +/- 3.3 vs 15.9 +/- 2.7) and VE/VCO(2) slope (35.7 +/- 7.8 vs 25.7 +/- 2.7). In patients, OUES was significantly (p < 0.001) correlated with LVEF (r = 0.54), BNP levels (r = -0.49), peak VO(2) (r = 0.80), VO(2) AT (r = 0.65) and VE/VCO(2) slope (r = -0.59). BNP was independently related to OUES in multivariate regression analysis. CONCLUSIONS: Oxygen uptake efficiency slope is significantly reduced in patients with CHF and correlates with peak VO(2) and other parameters of cardiopulmonary exercise treadmill test. It is not related to age. BNP is an independent marker of OUES in patients with CHF. |
| | |
Authors:
|
Ewa Straburzyńska-Migaj; Adrian Gwizdała; Andrzej Siniawski; Romuald Ochotny; Stefan Grajek |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Cardiology journal Volume: 17 ISSN: 1897-5593 ISO Abbreviation: Cardiol J Publication Date: 2010 |
Date Detail:
|
Created Date: 2010-08-06 Completed Date: 2010-11-22 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101392712 Medline TA: Cardiol J Country: Poland |
Other Details:
|
Languages: eng Pagination: 362-6 Citation Subset: IM |
Affiliation:
|
1st Department of Cardiology, University School of Medical Sciences, Długa 1/2, Poznań, Poland. ewa.migaj-straburzynska@skpp.edu.pl |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Biological Markers / blood Case-Control Studies Chi-Square Distribution Chronic Disease Exercise Test* Exercise Tolerance* Female Heart Failure / blood, diagnosis*, physiopathology Humans Male Middle Aged Multivariate Analysis Natriuretic Peptide, Brain / blood* Oxygen / metabolism* Oxygen Consumption* Poland Predictive Value of Tests Prognosis Pulmonary Ventilation Regression Analysis Stroke Volume Ventricular Function, Left |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; 114471-18-0/Natriuretic Peptide, Brain; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Coronary computed tomography angiography in dialysis patients undergoing pre-renal transplantation c...
Next Document: The modified Selvester QRS score: can we predict successful ST segment resolution in patients with m...