Document Detail


Oxygen transport in isolated cardiac myocytes.
MedLine Citation:
PMID:  4062838     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A preparation of isolated cardiac myocytes, retaining functional and structural properties of myocytes in the intact heart, has been used to measure intracellular oxygen pressure gradients. These are shallow and do not exceed 2 torr. Oxygen does not limit mitochondrial function in the cardiac myocyte until intracellular myoglobin is almost entirely deoxygenated. Most of the large oxygen pressure gradient in the working heart must be extracellular.
Authors:
B A Wittenberg; J B Wittenberg; I R Katz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Basic research in cardiology     Volume:  80 Suppl 2     ISSN:  0300-8428     ISO Abbreviation:  Basic Res. Cardiol.     Publication Date:  1985  
Date Detail:
Created Date:  1985-11-26     Completed Date:  1985-11-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0360342     Medline TA:  Basic Res Cardiol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  75-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Transport
Cell Separation
Mitochondria, Heart / metabolism
Myocardium / cytology*,  metabolism
Myoglobin / metabolism
Oxygen / metabolism*,  physiology
Pressure
Rats
Grant Support
ID/Acronym/Agency:
1-K6-733//PHS HHS; HL 19299/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Myoglobin; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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