Document Detail

Oxygen transport in cardiogenic and septic shock.
MedLine Citation:
PMID:  2026028     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To review clinical studies of oxygen transport in cardiogenic and septic shock. DESIGN: Descriptive and prospective studies. SETTING: University hospital multi disciplinary ICU. PATIENTS: Critically ill cardiogenic and septic shock patients greater than 18 and less than 80 yrs of age. INTERVENTIONS: The responses to volume loading with colloid or crystalloid and infusion of catecholamines are documented with baseline hemodynamic and oxygen transport measurements before and after administration of catecholamines. MEASUREMENTS AND MAIN RESULTS: Nineteen patients in cardiogenic shock were studied. In three patients, invasive systemic mean arterial pressure was greater than 80 mm Hg and cardiac index was greater than 2.0 L/min.m2. In all patients, there were increases in oxygen extraction ratio that averaged 48 +/- 18 (SD) %. However, in 30 septic shock patients, extraction ratio was 24 +/- 2%. In both groups, the response to therapy was an increase in mixed venous oxygen saturation from 54 +/- 16% to 69 +/- 8% in cardiogenic patients (p less than .001) and from 75 +/- 2% to 80 +/- 1% in septic shock (p less than .01). CONCLUSIONS: There are widely differing oxygen transport patterns in cardiogenic and septic shock that may have implications for therapy.
J D Edwards
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Critical care medicine     Volume:  19     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  1991 May 
Date Detail:
Created Date:  1991-06-13     Completed Date:  1991-06-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  658-63     Citation Subset:  AIM; IM    
Intensive Care Unit, University Hospital of South Manchester, West Didsbury, UK.
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MeSH Terms
Biological Transport
Oxygen / blood*
Respiration, Artificial
Shock, Cardiogenic / blood*,  physiopathology,  therapy
Shock, Septic / blood*,  physiopathology,  therapy
Reg. No./Substance:

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