Document Detail

Oxygen transport during hemodilution in normoxic and hypoxic dogs treated with verapamil.
MedLine Citation:
PMID:  6666529     Owner:  NLM     Status:  MEDLINE    
In order to determine the possible limitations of acute isovolemic hemodilution in patients taking verapamil, the various factors determining oxygen availability were analyzed in an animal experiment. Twenty-four anaesthetized dogs were subjected to a gradual isovolemic hemodilution. Six dogs received a bolus injection of 0.1 mg kg-1 of verapamil followed by 0.01 mg kg-1 min-1. In 12 dogs, mild hypoxic hypoxia was induced by ventilation with 16-17% oxygen; six of them also received verapamil. Six dogs served as a control group. In the latter, due to an increase in heart rate and stroke volume, oxygen availability in the clinically relevant range of hemodilution between HC 25 and 25% was maintained at 81% of its control value. In normoxic animals treated with verapamil, oxygen availability decreased more rapidly and was below the level of the control group once HC reached 25%. Mild hypoxic hypoxia alone did not reduce oxygen availability as much as its combination with verapamil. Even though the verapamil-induced reduction in oxygen availability was similar during normoxia and hypoxia, the sharp rise in serum lactate at HC levels below 35-30% in the hypoxic verapamil group was a sign of impairment of tissue oxygenation. Hematocrit levels below 35-30% and even moderate hypoxemia should be avoided whenever the cardiovascular response to hemodilution is influenced by verapamil.
R Scherer; M Wendt; U Schneider; S Kober; P Lawin
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Acta anaesthesiologica Scandinavica     Volume:  27     ISSN:  0001-5172     ISO Abbreviation:  Acta Anaesthesiol Scand     Publication Date:  1983 Dec 
Date Detail:
Created Date:  1984-03-06     Completed Date:  1984-03-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370270     Medline TA:  Acta Anaesthesiol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  495-500     Citation Subset:  IM; S    
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MeSH Terms
Anoxia / chemically induced*
Biological Transport / drug effects
Hemodynamics / drug effects
Lactates / blood
Oxygen / blood
Oxygen Consumption / drug effects*
Verapamil / adverse effects*
Reg. No./Substance:
0/Lactates; 52-53-9/Verapamil; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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