Document Detail

Oxygen toxicity is not related to mammalian body size.
MedLine Citation:
PMID:  2904337     Owner:  NLM     Status:  MEDLINE    
1. Small mammals have been used to study the effects of O2 toxicity. The aim of the present study was to investigate whether body size should be considered when applying the results of these studies to man. 2. Oxygen toxicity is enhanced as perfusion and metabolism increase: specific animal tissues of high perfusion are more susceptible to O2 toxicity. Exercise, high metabolic rate, and increased brain blood flow enhance O2 toxicity. 3. Increased specific O2 consumption and perfusion as body mass decreases may enhance O2 toxicity in small mammals. 4. Survival time in normobaric hyperoxia (1 atm O2) and the time to first appearance of convulsions in hyperbaric oxygen (4-5 atm) were collected from the literature and showed no relation to body size. 5. Known difference in antioxidant enzyme activity cannot explain the findings. 6. Independence of tissue PO2 on body size, or equal rates of free radical formation and degradation, are suggested as possible mechanisms. 7. Small mammals can serve as a good model for O2 toxicity in man.
R Arieli
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Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  Comparative biochemistry and physiology. A, Comparative physiology     Volume:  91     ISSN:  0300-9629     ISO Abbreviation:  Comp Biochem Physiol A Comp Physiol     Publication Date:  1988  
Date Detail:
Created Date:  1989-01-26     Completed Date:  1989-01-26     Revised Date:  2008-10-30    
Medline Journal Info:
Nlm Unique ID:  1276312     Medline TA:  Comp Biochem Physiol A Comp Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  221-3     Citation Subset:  IM; S    
Israel Naval Hyperbaric Institute, Haifa.
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MeSH Terms
Body Constitution*
Oxygen / toxicity*
Oxygen Consumption
Seizures / chemically induced
Reg. No./Substance:

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