Document Detail


Oxygen toxicity is not related to mammalian body size.
MedLine Citation:
PMID:  2904337     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. Small mammals have been used to study the effects of O2 toxicity. The aim of the present study was to investigate whether body size should be considered when applying the results of these studies to man. 2. Oxygen toxicity is enhanced as perfusion and metabolism increase: specific animal tissues of high perfusion are more susceptible to O2 toxicity. Exercise, high metabolic rate, and increased brain blood flow enhance O2 toxicity. 3. Increased specific O2 consumption and perfusion as body mass decreases may enhance O2 toxicity in small mammals. 4. Survival time in normobaric hyperoxia (1 atm O2) and the time to first appearance of convulsions in hyperbaric oxygen (4-5 atm) were collected from the literature and showed no relation to body size. 5. Known difference in antioxidant enzyme activity cannot explain the findings. 6. Independence of tissue PO2 on body size, or equal rates of free radical formation and degradation, are suggested as possible mechanisms. 7. Small mammals can serve as a good model for O2 toxicity in man.
Authors:
R Arieli
Related Documents :
2384417 - Effect of exercise intensity and duration on postexercise metabolism.
9493347 - Oxygen consumption in myoglobin-rich and myoglobin-poor isolated fish cardiomyocytes.
10691227 - Critical oxygen delivery in conscious humans is less than 7.3 ml o2 x kg(-1) x min(-1).
9585017 - Hypoxemic resuscitation in newborn piglets: recovery of somatosensory evoked potentials...
2344757 - Measurement of tidal volume using a pneumotachometer during high-frequency oscillation.
12381747 - Effects of exercise training on thermoregulatory responses and blood volume in older men.
Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  Comparative biochemistry and physiology. A, Comparative physiology     Volume:  91     ISSN:  0300-9629     ISO Abbreviation:  Comp Biochem Physiol A Comp Physiol     Publication Date:  1988  
Date Detail:
Created Date:  1989-01-26     Completed Date:  1989-01-26     Revised Date:  2008-10-30    
Medline Journal Info:
Nlm Unique ID:  1276312     Medline TA:  Comp Biochem Physiol A Comp Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  221-3     Citation Subset:  IM; S    
Affiliation:
Israel Naval Hyperbaric Institute, Haifa.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Body Constitution*
Mammals
Oxygen / toxicity*
Oxygen Consumption
Seizures / chemically induced
Chemical
Reg. No./Substance:
7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Prevention of cancer: restriction of nutritional energy intake (joules).
Next Document:  Low-sodium contractures indicating sarcolemmal Na/Ca-exchange in the frog heart.