| Oxygen toxicity in premature infants. | |
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MedLine Citation:
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PMID: 12030843 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Oxygen causes tissue injury through the formation of reactive oxygen intermediates and peroxidation of membrane lipids. Premature infants, who have severely reduced antioxidant defenses, are particularly sensitive to the toxic effects of oxygen. Supplemental oxygen in premature infants contributes to the development of chronic lung disease (bronchopulmonary dysplasia), characterized by dysregulated inflammation and altered expression of proteases and growth factors. This can result in fibrosis, asymmetric aeration, and respiratory insufficiency. Oxygen also induces aberrant physiologic responses that can be damaging in premature infants. For example, vasoconstriction in the retina is an early response to oxygen that can lead to vasoobliteration, neovascularization, and retinal traction (retinopathy of prematurity). Increasing knowledge of the mechanisms underlying oxygen toxicity in premature infants has suggested strategies to minimize tissue injury and to optimize long-term medical outcomes. These include limiting oxygen supplementation and light exposure, the use of antiinflammatory agents or antioxidants, and the use of room air in neonatal resuscitation. |
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Authors:
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Barry Weinberger; Debra L Laskin; Diane E Heck; Jeffrey D Laskin |
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22633503 - Fluconazole use and safety in the nursery. 602753 - Oxygen therapy and massive pulmonary haemorrhage in newborn infants. 22110293 - The factors contributing to the risk of sudden infant death syndrome. |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Toxicology and applied pharmacology Volume: 181 ISSN: 0041-008X ISO Abbreviation: Toxicol. Appl. Pharmacol. Publication Date: 2002 May |
Date Detail:
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Created Date: 2002-05-28 Completed Date: 2002-06-26 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 0416575 Medline TA: Toxicol Appl Pharmacol Country: United States |
Other Details:
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Languages: eng Pagination: 60-7 Citation Subset: IM |
Copyright Information:
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(c) 2002 Elsevier Science (USA). |
Affiliation:
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Department of Pediatrics/Neonatology, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antioxidants
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metabolism,
therapeutic use Bronchopulmonary Dysplasia / etiology, pathology, prevention & control Chronic Disease Humans Infant, Newborn Infant, Premature* Oxygen Inhalation Therapy / adverse effects* Retinopathy of Prematurity / etiology, pathology, prevention & control |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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