| Oxygen tissue saturation is lower in nonsurvivors than in survivors after early resuscitation of septic shock. | |
| | |
MedLine Citation:
|
PMID: 19602965 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Growing evidence suggests that the microvascular dysfunction is the key element of the pathogenesis of septic shock. This study's purpose was to explore whether the outcome of septic shock patients after early resuscitation using early goal-directed therapy is related to their muscle tissue oxygenation. METHODS: Tissue oxygen saturation (Sto2) was monitored in septic shock patients using a tissue spectrometer (InSpectra Model 325; Hutchinson Technology, Hutchinson, MN). For the purpose of this retrospective study, the Sto2 values were collected at the first measurement done after the macrohemodynamic variables (mean arterial pressure, urine output, central venous saturation in oxygen) were optimized. RESULTS: After the hemodynamic variables were corrected, no difference was observed between the nonsurvivors and survivors, with the exception of pulse oximetry saturation (94% [92-97%] vs. 97% [94-99%], P = 0.04). The Sto2 values were significantly lower in the nonsurvivors than in the survivors (73% [68-82%] vs. 84% [81-90%], P = 0.02). No correlations were found between the Sto2 and Spo2 (P = 0.7). CONCLUSIONS: In septic shock patients, tissue oxygen saturation below 78% is associated with increased mortality at day 28. Further investigations are required to determine whether the correction of an impaired level of tissue oxygen saturation may improve the outcome of these patients. |
| | |
Authors:
|
Marc Leone; Sami Blidi; François Antonini; Bertrand Meyssignac; Sébastien Bordon; Frédéric Garcin; Aude Charvet; Valéry Blasco; Jacques Albanèse; Claude Martin |
Related Documents
:
|
2789585 - The role of pulse oximetry in the accident and emergency department. 1319255 - The incidence and severity of hypoxia associated with 99tcm technegas ventilation scint... 8213865 - Ehrlichiosis presenting as a life-threatening illness with features of the toxic shock ... 1935155 - Effect of vasoactive treatment on the relationship between mixed venous and regional ox... 18611365 - Early intervention: which patients and how early? 6581705 - Comprehensive monitoring and computerized tomographic follow up in patients with acute ... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Anesthesiology Volume: 111 ISSN: 1528-1175 ISO Abbreviation: Anesthesiology Publication Date: 2009 Aug |
Date Detail:
|
Created Date: 2009-07-24 Completed Date: 2009-08-25 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 1300217 Medline TA: Anesthesiology Country: United States |
Other Details:
|
Languages: eng Pagination: 366-71 Citation Subset: AIM; IM |
Affiliation:
|
Service d'Anesthésie et de Réanimation, Hôpital Nord, Assistance Publique-Hôpitaux de Marseille and Université de la Méditerranée, Marseille, France. marc.leone@ap-hm.fr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Capillaries / pathology Carbon Dioxide / blood Cohort Studies Creatinine / blood Female Hemodynamics / physiology Humans Intensive Care Units Male Middle Aged Muscle, Skeletal / metabolism Oximetry Oxygen / blood Oxygen Consumption / physiology* ROC Curve Resuscitation Retrospective Studies Shock, Septic / metabolism*, mortality*, physiopathology Spectroscopy, Near-Infrared Survival Analysis Survivors |
| Chemical | |
Reg. No./Substance:
|
124-38-9/Carbon Dioxide; 60-27-5/Creatinine; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Clonidine as an adjuvant to local anesthetics for peripheral nerve and plexus blocks: a meta-analysi...
Next Document: Influence of vancomycin on renal function in critically ill patients after cardiac surgery: continuo...