Document Detail

Oxygen tissue saturation is lower in nonsurvivors than in survivors after early resuscitation of septic shock.
MedLine Citation:
PMID:  19602965     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Growing evidence suggests that the microvascular dysfunction is the key element of the pathogenesis of septic shock. This study's purpose was to explore whether the outcome of septic shock patients after early resuscitation using early goal-directed therapy is related to their muscle tissue oxygenation. METHODS: Tissue oxygen saturation (Sto2) was monitored in septic shock patients using a tissue spectrometer (InSpectra Model 325; Hutchinson Technology, Hutchinson, MN). For the purpose of this retrospective study, the Sto2 values were collected at the first measurement done after the macrohemodynamic variables (mean arterial pressure, urine output, central venous saturation in oxygen) were optimized. RESULTS: After the hemodynamic variables were corrected, no difference was observed between the nonsurvivors and survivors, with the exception of pulse oximetry saturation (94% [92-97%] vs. 97% [94-99%], P = 0.04). The Sto2 values were significantly lower in the nonsurvivors than in the survivors (73% [68-82%] vs. 84% [81-90%], P = 0.02). No correlations were found between the Sto2 and Spo2 (P = 0.7). CONCLUSIONS: In septic shock patients, tissue oxygen saturation below 78% is associated with increased mortality at day 28. Further investigations are required to determine whether the correction of an impaired level of tissue oxygen saturation may improve the outcome of these patients.
Marc Leone; Sami Blidi; François Antonini; Bertrand Meyssignac; Sébastien Bordon; Frédéric Garcin; Aude Charvet; Valéry Blasco; Jacques Albanèse; Claude Martin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anesthesiology     Volume:  111     ISSN:  1528-1175     ISO Abbreviation:  Anesthesiology     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-24     Completed Date:  2009-08-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1300217     Medline TA:  Anesthesiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  366-71     Citation Subset:  AIM; IM    
Service d'Anesthésie et de Réanimation, Hôpital Nord, Assistance Publique-Hôpitaux de Marseille and Université de la Méditerranée, Marseille, France.
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MeSH Terms
Capillaries / pathology
Carbon Dioxide / blood
Cohort Studies
Creatinine / blood
Hemodynamics / physiology
Intensive Care Units
Middle Aged
Muscle, Skeletal / metabolism
Oxygen / blood
Oxygen Consumption / physiology*
ROC Curve
Retrospective Studies
Shock, Septic / metabolism*,  mortality*,  physiopathology
Spectroscopy, Near-Infrared
Survival Analysis
Reg. No./Substance:
124-38-9/Carbon Dioxide; 60-27-5/Creatinine; 7782-44-7/Oxygen

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