| Oxygen therapy reduces secondary hemorrhage after thrombolysis in thromboembolic cerebral ischemia. | |
| | |
MedLine Citation:
|
PMID: 20424638 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Hyperbaric oxygen (HBO) and normobaric hyperoxia (NBO) protect the brain parenchyma and the cerebral microcirculation against ischemia. We studied their effect on secondary hemorrhage after thrombolysis in two thromboembolic middle cerebral artery occlusion (MCAO) (tMCAO) models. Beginning 60 minutes after tMCAO with either thrombin-induced thromboemboli (TT) or calcium-induced thromboemboli (CT), spontaneously hypertensive rats (n=96) breathed either air, 100% O(2) (NBO), or 100% O(2) at 3 bar (HBO) for 1 hour. Immediately thereafter, recombinant tissue plasminogen activator (rt-PA, 9 mg/kg) was injected. Although significant reperfusion was observed after thrombolysis in TT-tMCAO, vascular occlusion persisted in CT-tMCAO. In TT-tMCAO, NBO and HBO significantly reduced diffusion-weighted imaging-magnetic resonance imaging (MRI) lesion volume and postischemic blood-brain barrier (BBB) permeability on postcontrast T1-weighted images. NBO and, significantly more potently, HBO reduced macroscopic hemorrhage on T2* MRI and on corresponding postmortem cryosections. Oxygen therapy lowered hemoglobin content and attenuated activation of matrix metalloproteinases in the ischemic hemisphere. In contrast, NBO and HBO failed to reduce infarct size in CT but both decreased BBB damage and microscopic hemorrhagic transformation. Only HBO reduced hemoglobin extravasation in the ischemic hemisphere. In conclusion, NBO and HBO decrease infarct size after thromboembolic ischemia only if recanalization is successful. As NBO and HBO also reduce postthrombolytic intracerebral hemorrhage, combining the two with thrombolysis seems promising. |
| | |
Authors:
|
Li Sun; Wei Zhou; Christian Mueller; Clemens Sommer; Sabine Heiland; Alexander T Bauer; Hugo H Marti; Roland Veltkamp |
Related Documents
:
|
6540398 - Schizencephaly: a clinical and ct study. 3387158 - Local cerebral blood flow as assessed by xenon stable computed tomography in child drow... 19706998 - Cerebral microbleeds in patients with intracerebral hemorrhage are associated with prev... 8162638 - Magnetic resonance imaging (mri) of the brain in sle: eclam and sledai correlations. 8948158 - Magnetic resonance angiography of the origins of the supraaortic arteries: comparison o... 17853298 - Frontolimbic glutamate alterations in first episode schizophrenia: evidence from a magn... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-04-28 |
Journal Detail:
|
Title: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Volume: 30 ISSN: 1559-7016 ISO Abbreviation: J. Cereb. Blood Flow Metab. Publication Date: 2010 Sep |
Date Detail:
|
Created Date: 2010-09-02 Completed Date: 2010-10-19 Revised Date: 2011-09-13 |
Medline Journal Info:
|
Nlm Unique ID: 8112566 Medline TA: J Cereb Blood Flow Metab Country: United States |
Other Details:
|
Languages: eng Pagination: 1651-60 Citation Subset: IM |
Affiliation:
|
Department of Neurology, Ruprecht-Karls-University Heidelberg, Heidelberg, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood-Brain Barrier Brain Ischemia / complications*, drug therapy*, pathology Cerebral Hemorrhage / etiology, pathology, prevention & control* Data Interpretation, Statistical Erythrocytes / physiology Fibrinolytic Agents / adverse effects* Gelatin Hemoglobins / metabolism Image Processing, Computer-Assisted Infarction, Middle Cerebral Artery / complications, drug therapy, pathology Magnetic Resonance Imaging Male Matrix Metalloproteinase 9 / biosynthesis Oxygen Inhalation Therapy* Rats Rats, Sprague-Dawley Thrombin Thromboembolism / chemically induced, complications*, drug therapy* |
| Chemical | |
Reg. No./Substance:
|
0/Fibrinolytic Agents; 0/Hemoglobins; 9000-70-8/Gelatin; EC 3.4.21.5/Thrombin; EC 3.4.24.35/Matrix Metalloproteinase 9 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Bilirubin oxidation end products directly alter K+ channels important in the regulation of vascular ...
Next Document: Comparative genomic analysis reveals species-dependent complexities that explain difficulties with m...