| Oxygen therapy for hypercapnic patients with chronic obstructive pulmonary disease and acute respiratory failure: a randomized, controlled pilot study. | |
| | |
MedLine Citation:
|
PMID: 11905405 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To investigate the effect of oxygen therapy on outcome and on symptomatic hypercapnia. DESIGN: Randomized, controlled, single-blind study. SETTING: Multidisciplinary intensive care unit of a university teaching hospital. PATIENTS: Patients admitted with a clinical diagnosis of an acute exacerbation of chronic obstructive pulmonary disease and a PaO2 <6.6 kPa (50 mm Hg) and PaCO2 >6.6 kPa (50 mm Hg) on air. INTERVENTIONS: Patients received oxygen therapy titrated to increase arterial oxygen tension to >6.6 kPa (50 mm Hg) or >9 kPa (70 mm Hg). Patients in the low-oxygen tension group also received doxapram if they developed an acidosis with pH <7.2, whereas those in the high-oxygen tension group received doxapram if they developed symptomatic acidosis. Bronchodilator, steroid, and antibiotic therapy was standardized. MEASUREMENTS AND MAIN RESULTS: Two patients in the low-oxygen tension group (n = 17) required mechanical ventilation and another one died. No patients in the high-oxygen group (n = 17) had a poor outcome, but this difference was not significant. No patient in either group became comatose or developed an acute cardiac arrhythmia. CONCLUSIONS: Traditional teaching related to oxygen therapy for hypercapnic patients with an acute exacerbation of chronic obstructive pulmonary disease may be incorrect. A large randomized, controlled study is required to confirm this impression. |
| | |
Authors:
|
Charles D Gomersall; Gavin M Joynt; Ross C Freebairn; Christopher K W Lai; Teik E Oh |
Related Documents
:
|
16432295 - Noninvasive positive pressure ventilation in patients with respiratory failure due to s... 15682425 - Surgical lung biopsy in patients with hematological malignancy or hematopoietic stem ce... 20217045 - Effectiveness of acetazolamide for reversal of metabolic alkalosis in weaning copd pati... 1489115 - A comparative study of the effects of almitrine bismesylate and lateral position during... 15615755 - Necrotising retinopathies simulating acute retinal necrosis syndrome. 1970215 - Mild tardive dyskinesia: an 8-year follow-up study. |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Critical care medicine Volume: 30 ISSN: 0090-3493 ISO Abbreviation: Crit. Care Med. Publication Date: 2002 Jan |
Date Detail:
|
Created Date: 2002-03-20 Completed Date: 2002-04-05 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0355501 Medline TA: Crit Care Med Country: United States |
Other Details:
|
Languages: eng Pagination: 113-6 Citation Subset: AIM; IM |
Affiliation:
|
Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Female Humans Male Oxygen Inhalation Therapy* Pulmonary Disease, Chronic Obstructive / therapy* Respiration, Artificial Respiratory Insufficiency / therapy* |
| Comments/Corrections | |
Comment In:
|
Crit Care Med. 2002 Jan;30(1):258-9
[PMID:
11902279
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Adrenomedullin, calcitonin gene-related peptide and their receptors: evidence for a decreased placen...
Next Document: No effect of preoperative selective gut decontamination on endotoxemia and cytokine activation durin...