| Oxygen tension in rat cerebral cortex microvessels in acute anemia. | |
| | |
MedLine Citation:
|
PMID: 18607751 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Polarigraphic microelectrodes were used to study the distribution of oxygen tension (pO(2)) in arterioles (lumen diameters 8-80 microm) and venules (lumen diameters 8-120 microm) in the rat cerebral cortex during acute reductions in blood hemoglobin ([Hb]). Isovolumic hemodilution with 5% albumin solution was performed in steps from an initial [Hb] of 14.1 +/- 0.3 g/dl (control) to 9.8 +/- 0.3 g/dl (step 1), 6.6 +/- 0.4 g/dl (step 2), and 4.6 +/- 0.3 g/dl (step 3). Mild anemia (step 1, hematocrit 30%) led to an increase in pO(2) in the arterial side of the microcirculatory bed, with virtually no change in pO(2) in the venous side. Step 2 (hematocrit 20%) was accompanied by a further insignificant increase in pO(2) in arterioles, while there was a significant reduction (on average to 32 mmHg) in venules. Step 3 (hematocrit 13-14%) led to a (statistically insignificant) increase in pO(2) in arterioles. pO(2) in venules decreased, on average, to 27 mmHg; the proportion of smallest venules with low pO(2) values (less than 20 mmHg) increased to 31% (from 3% in controls). In some capillaries, pO(2) was 5-10 mmHg, which was an indicator of the presence of hypoxic zones in brain tissues. These zones primarily arose close to the smallest capillary and venous microvessels, with slowed or impaired blood flow. |
| | |
Authors:
|
E P Vovenko; A E Chuikin |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-07-08 |
Journal Detail:
|
Title: Neuroscience and behavioral physiology Volume: 38 ISSN: 0097-0549 ISO Abbreviation: Neurosci. Behav. Physiol. Publication Date: 2008 Jun |
Date Detail:
|
Created Date: 2008-08-12 Completed Date: 2008-12-09 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0330471 Medline TA: Neurosci Behav Physiol Country: United States |
Other Details:
|
Languages: eng Pagination: 493-500 Citation Subset: IM |
Affiliation:
|
Tissue Gas Exchange Physiology Group, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, 6 Makarov Bank, St. Petersburg, Russia. epv@infran.ru |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acute Disease Anemia / blood, complications, metabolism* Animals Anoxia / blood*, etiology Arterioles / metabolism Cerebral Cortex / blood supply, metabolism* Disease Models, Animal Hemoglobins / deficiency, metabolism* Male Oxygen / blood Oxygen Consumption / physiology* Rats Rats, Wistar Severity of Illness Index Venules / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Hemoglobins; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The role of serotonin in the pathogenesis and clinical presentations of migraine attacks.
Next Document: Glutamatergic regulation of extracellular citrulline levels in the nucleus accumbens during an emoti...