| Oxygen supply, oxygen consumption, and endocrine and exocrine secretions of the isolated, perfused, porcine pancreas. | |
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MedLine Citation:
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PMID: 6108678 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We studied the effect of varying oxygen supply on the endocrine and exocrine secretions of the isolated perfused porcine pancreas utilizing completely synthetic perfusion medium with and without the addition of erythrocytes. With synthetic medium oxygenated to a Po2 of 500 mmHg, oxygen consumption was constant for flow rates at or above 0.5 ml x min-1 x g-1 (wet weight). Addition of erythrocytes to the medium did not increase oxygen consumption at flow rates above this level. Furthermore, the secretion of fluid, bicarbonate and protein in response to secretin and acetylcholine was not influenced by addition of erythrocytes. Similarly, the secretion of insulin, glucagon, pancreatic polypeptide, and somatostatin in response to arginine and acetylcholine was unchanged; arginine stimulated the secretion of all four peptides, whereas acetylcholine stimulated the secretion of insulin and pancreatic polypeptide and inhibited glucagon and somatostatin secretion. The results indicate that the porcine pancreas is respiring adequately, when perfused with a completely synthetic perfusion medium at flows above about 0.5 ml x min-1 x g-1 and Po2 about 500 mmHg, and that addition of erythrocytes is not necessary for the study of its secretory functions. |
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Authors:
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J J Holst; S L Jensen; O V Nielsen; T W Schwartz |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta physiologica Scandinavica Volume: 109 ISSN: 0001-6772 ISO Abbreviation: Acta Physiol. Scand. Publication Date: 1980 May |
Date Detail:
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Created Date: 1981-02-24 Completed Date: 1981-02-24 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370362 Medline TA: Acta Physiol Scand Country: SWEDEN |
Other Details:
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Languages: eng Pagination: 7-13 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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pharmacology Animals Arginine / pharmacology Erythrocytes / physiology Glucagon / secretion Insulin / secretion Oxygen / metabolism* Oxygen Consumption* Pancreas / drug effects, physiology, secretion* Pancreatic Polypeptide / secretion Perfusion Secretin / diagnostic use Somatostatin / secretion Swine |
| Chemical | |
Reg. No./Substance:
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11061-68-0/Insulin; 1393-25-5/Secretin; 51-84-3/Acetylcholine; 51110-01-1/Somatostatin; 59763-91-6/Pancreatic Polypeptide; 74-79-3/Arginine; 7782-44-7/Oxygen; 9007-92-5/Glucagon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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