Document Detail

Oxygen uptake/oxygen supply dependency: fact or fiction?
MedLine Citation:
PMID:  8599284     Owner:  NLM     Status:  MEDLINE    
More than a decade ago, observations of co-variance between VO2 and DO2 led to the identification of a condition known as pathological O2 supply dependency. This condition was subsequently observed in critically ill patients with sepsis and acute circulatory failure. More recently, other authors have challenged the existence of this condition, often citing methodologic problems or mathematical coupling to account for spurious observations in the earlier studies. Here, we review the evidence for and against pathological O2 supply dependency. We find that many of the arguments have some validity but only in specific circumstances. We conclude, therefore, that pathological O2 supply dependency is a hallmark of acute circulatory failure and that an effective therapeutic approach should be based on an evaluation of organ system function in each individual case. Parameters such as blood lactate, pHi and veno-arterial PCO2 may be useful in this respect.
J L Vincent; D De Backer
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Acta anaesthesiologica Scandinavica. Supplementum     Volume:  107     ISSN:  0515-2720     ISO Abbreviation:  Acta Anaesthesiol Scand Suppl     Publication Date:  1995  
Date Detail:
Created Date:  1996-04-24     Completed Date:  1996-04-24     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0370271     Medline TA:  Acta Anaesthesiol Scand Suppl     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  229-37     Citation Subset:  IM    
Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Belgium.
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MeSH Terms
Bacterial Infections / blood
Carbon Dioxide / blood
Critical Illness
Hydrogen-Ion Concentration
Lactates / blood
Oxygen / blood*
Oxygen Consumption*
Reproducibility of Results
Shock / blood,  therapy
Reg. No./Substance:
0/Lactates; 124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

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