| Oxygen supplementation increases glucose tolerance during euglycaemic hyperinsulinaemic glucose clamp procedure in patients with severe COPD and chronic hypoxaemia. | |
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MedLine Citation:
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PMID: 16939503 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Investigations in chronic obstructive pulmonary disease (COPD) patients have shown impaired glucose tolerance in hypoxic COPD patients, compared with COPD patients with normal arterial blood gases. In healthy subjects, hypoxaemia or stay at altitude, have been shown to alter glucose metabolism. At altitude the effect seems to be dependent on duration of stay. A short stay is associated with insulin resistance, a longer stay gives rise to increased glucose uptake. The euglycaemic hyperinsulinaemic glucose clamp technique is a method to study glucose tolerance and enables determinations of glucose clearance in peripheral tissues. We investigated six COPD patients [forced expiratory volume in 1 s 0.7 +/- 0.2 l (mean +/- SD)] with chronic hypoxaemia (PaO(2) 7.9 +/- 0.6 kPa at rest, breathing air), with and without oxygen supplementation, using the glucose clamp technique. Net peripheral glucose uptake was 5.5 +/- 1.2 and 7.1 +/- 1.6 mg (kg*min)(-1) (+29%) breathing air and supplemental oxygen, respectively (P = 0.03). The tissue sensitivity to insulin increased 32% (P = 0.03) with oxygen supplementation. The results indicate that normalization of oxygen saturation in COPD patients with chronic hypoxaemia may have an immediate effect on glucose tolerance and tissue sensitivity to insulin in these patients. |
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Authors:
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P Jakobsson; L Jorfeldt |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical physiology and functional imaging Volume: 26 ISSN: 1475-0961 ISO Abbreviation: Clin Physiol Funct Imaging Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-08-30 Completed Date: 2007-01-03 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101137604 Medline TA: Clin Physiol Funct Imaging Country: England |
Other Details:
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Languages: eng Pagination: 271-4 Citation Subset: IM |
Affiliation:
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Department of Pulmonary Medicine, University Hospital, Linköping, Sweden. per.jakobsson@lio.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Anoxia / therapy* Female Glucose / metabolism* Glucose Clamp Technique / methods* Glucose Intolerance / therapy Humans Insulin / metabolism Male Middle Aged Oxygen / metabolism, therapeutic use* Oxygen Inhalation Therapy* Pulmonary Disease, Chronic Obstructive / therapy* Time Factors |
| Chemical | |
Reg. No./Substance:
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11061-68-0/Insulin; 50-99-7/Glucose; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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