Document Detail

Oxygen supplementation increases glucose tolerance during euglycaemic hyperinsulinaemic glucose clamp procedure in patients with severe COPD and chronic hypoxaemia.
MedLine Citation:
PMID:  16939503     Owner:  NLM     Status:  MEDLINE    
Investigations in chronic obstructive pulmonary disease (COPD) patients have shown impaired glucose tolerance in hypoxic COPD patients, compared with COPD patients with normal arterial blood gases. In healthy subjects, hypoxaemia or stay at altitude, have been shown to alter glucose metabolism. At altitude the effect seems to be dependent on duration of stay. A short stay is associated with insulin resistance, a longer stay gives rise to increased glucose uptake. The euglycaemic hyperinsulinaemic glucose clamp technique is a method to study glucose tolerance and enables determinations of glucose clearance in peripheral tissues. We investigated six COPD patients [forced expiratory volume in 1 s 0.7 +/- 0.2 l (mean +/- SD)] with chronic hypoxaemia (PaO(2) 7.9 +/- 0.6 kPa at rest, breathing air), with and without oxygen supplementation, using the glucose clamp technique. Net peripheral glucose uptake was 5.5 +/- 1.2 and 7.1 +/- 1.6 mg (kg*min)(-1) (+29%) breathing air and supplemental oxygen, respectively (P = 0.03). The tissue sensitivity to insulin increased 32% (P = 0.03) with oxygen supplementation. The results indicate that normalization of oxygen saturation in COPD patients with chronic hypoxaemia may have an immediate effect on glucose tolerance and tissue sensitivity to insulin in these patients.
P Jakobsson; L Jorfeldt
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical physiology and functional imaging     Volume:  26     ISSN:  1475-0961     ISO Abbreviation:  Clin Physiol Funct Imaging     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-30     Completed Date:  2007-01-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101137604     Medline TA:  Clin Physiol Funct Imaging     Country:  England    
Other Details:
Languages:  eng     Pagination:  271-4     Citation Subset:  IM    
Department of Pulmonary Medicine, University Hospital, Linköping, Sweden.
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MeSH Terms
Anoxia / therapy*
Glucose / metabolism*
Glucose Clamp Technique / methods*
Glucose Intolerance / therapy
Insulin / metabolism
Middle Aged
Oxygen / metabolism,  therapeutic use*
Oxygen Inhalation Therapy*
Pulmonary Disease, Chronic Obstructive / therapy*
Time Factors
Reg. No./Substance:
11061-68-0/Insulin; 50-99-7/Glucose; 7782-44-7/Oxygen

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