Document Detail

Oxygen status of arterial and mixed venous blood.
MedLine Citation:
PMID:  7600839     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To describe system requirements for determination of the oxygen status of the blood using the oxygen status algorithm, a computer program. To define the oxygen extractivity, a term we propose, of the arterial blood and the oxygen extraction tension. To describe the different causes of tissue hypoxia, and the clinical interpretation of mixed venous oxygen tension and oxygen consumption rate. DATA SOURCES: Previous physiological and clinical studies related to oxygen status of the blood. DATA SYNTHESIS: The oxygen status algorithm calculates the oxygen extraction tension and generates the oxygen graph as an aid in interpreting oxygen status of the patient. A cybernetic scheme explains the causes of tissue hypoxia and forms the basis for the interpretation of changes in the mixed venous oxygen tension. A diagram with the mixed venous oxygen tension on the abscissa and the oxygen consumption rate on the ordinate illustrates the oxygen flux dependent oxygen consumption rate. A graph shows the relationship between mixed venous oxygen tension and oxygen delivery. CONCLUSIONS: The oxygen status of arterial blood comprises three groups of quantities related to arterial oxygen tension, hemoglobin oxygen capacity, and hemoglobin oxygen affinity. Disturbances in one of these groups may be compensated by opposite changes in one or both of the other. The oxygen extraction tension indicates the degree of compensation, and mixed venous oxygen tension is the key parameter in evaluating the presence of a state of oxygen flux-dependent oxidative metabolism.
O Siggaard-Andersen; N Fogh-Andersen; I H Gøthgen; V H Larsen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Critical care medicine     Volume:  23     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  1995 Jul 
Date Detail:
Created Date:  1995-08-10     Completed Date:  1995-08-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1284-93     Citation Subset:  AIM; IM; S    
Department of Anesthesiology/Intensive Care Medicine, Herlev University Hospital, Copenhagen, Denmark.
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MeSH Terms
Anoxia / blood,  etiology
Blood Gas Analysis / instrumentation
Hemoglobins / analysis
Hydrogen-Ion Concentration
Oxygen / blood*
Oxygen Consumption
Partial Pressure
Reg. No./Substance:
0/Hemoglobins; 7782-44-7/Oxygen

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