Document Detail

Oxygen sensitivity of mitochondrial redox status and evoked potential recovery early during reperfusion in post-ischemic rat brain.
MedLine Citation:
PMID:  9667336     Owner:  NLM     Status:  MEDLINE    
Inspired oxygen (FiO2) was manipulated during the early reperfusion period after global cerebral ischemia (four-vessel occlusion of 20 or 30 min duration) in anesthetized rats. The goal was to determine whether oxygen availability during the early reperfusion period alters recovery of mitochondrial redox state and evoked electrical activity. The effectiveness of post-ischemic oxygen treatment was monitored at the tissue level with oxygen sensitive microelectrodes, and at the mitochondrial level by reflection spectrophotometry of the redox state of cytochrome oxidase. Transiently decreasing FiO2 from 0.3 to 0.15 limited reperfusion-induced hyperoxygenation and post-ischemic mitochondrial hyperoxidation (PIMHo). Evoked potential recovery was improved by this treatment after 20 min ischemia but not after 30 min ischemia. Increasing FiO2 from 0.3 to 1.0 exacerbated PIMHo and tissue hyperoxygenation. Transient elevation of tissue oxygen tension after 30 min of global ischemia inhibited recovery of evoked potentials. These data suggest that a period of heightened vulnerability to oxidative stress occurs within the first 10 min of reperfusion after global ischemia. This period is characterized by tissue hyperoxygenation and mitochondrial hyperoxidation. Limiting oxygen availability during this period may improve the outcome while conversely elevating oxygenation may be detrimental.
Z C Feng; T J Sick; M Rosenthal
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Resuscitation     Volume:  37     ISSN:  0300-9572     ISO Abbreviation:  Resuscitation     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-09-18     Completed Date:  1998-09-18     Revised Date:  2009-08-25    
Medline Journal Info:
Nlm Unique ID:  0332173     Medline TA:  Resuscitation     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  33-41     Citation Subset:  IM    
Department of Neurology, University of Miami School of Medicine, FL 33101, USA.
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MeSH Terms
Brain / metabolism,  physiopathology*
Brain Ischemia / metabolism,  physiopathology*
Electron Transport Complex IV / metabolism
Evoked Potentials / drug effects*
Extracellular Space / metabolism
Mitochondria / drug effects*,  metabolism*
Oxidation-Reduction / drug effects
Oxygen / pharmacology*
Potassium / metabolism
Rats, Wistar
Grant Support
Reg. No./Substance:
7440-09-7/Potassium; 7782-44-7/Oxygen; EC Transport Complex IV

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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