| Oxygen sensing in hypoxic pulmonary vasoconstriction: using new tools to answer an age-old question. | |
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MedLine Citation:
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PMID: 17993507 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hypoxic pulmonary vasoconstriction (HPV) becomes activated in response to alveolar hypoxia and, although the characteristics of HPV have been well described, the underlying mechanism of O(2) sensing which initiates the HPV response has not been fully established. Mitochondria have long been considered as a putative site of oxygen sensing because they consume O(2) and therefore represent the intracellular site with the lowest oxygen tension. However, two opposing theories have emerged regarding mitochondria-dependent O(2) sensing during hypoxia. One model suggests that there is a decrease in mitochondrial reactive oxygen species (ROS) levels during the transition from normoxia to hypoxia, resulting in the shift in cytosolic redox to a more reduced state. An alternative model proposes that hypoxia paradoxically increases mitochondrial ROS signalling in pulmonary arterial smooth muscle. Experimental resolution of the question of whether the mitochondrial ROS levels increase or decrease during hypoxia has been problematic owing to the technical limitations of the tools used to assess oxidant stress as well as the pharmacological agents used to inhibit the mitochondrial electron transport chain. However, recent developments in genetic techniques and redox-sensitive probes may allow us eventually to reach a consensus concerning the O(2) sensing mechanism underlying HPV. |
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Authors:
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Gregory B Waypa; Paul T Schumacker |
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Publication Detail:
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Type: Journal Article; Review Date: 2007-11-09 |
Journal Detail:
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Title: Experimental physiology Volume: 93 ISSN: 0958-0670 ISO Abbreviation: Exp. Physiol. Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2007-12-31 Completed Date: 2008-03-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9002940 Medline TA: Exp Physiol Country: England |
Other Details:
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Languages: eng Pagination: 133-8 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, North-western University, Ward Building 12-191, 303 East Chicago Avenue, Chicago, IL 60611, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anoxia / blood*, physiopathology* Humans Mitochondria / physiology Oxygen / blood* Pulmonary Circulation / physiology* Reactive Oxygen Species / metabolism Signal Transduction / physiology Vasoconstriction / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Reactive Oxygen Species; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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