Document Detail


Oxygen sensing in the carotid body.
MedLine Citation:
PMID:  19845614     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The carotid body (CB) is a neural crest-derived organ whose function is to elicit hyperventilation in response to hypoxemia. The CB contains clusters of neuron-like glomus cells enveloped by glia-like sustentacular cells. CB responsiveness to acute hypoxia relies on the inhibition of O2-sensitive K+ channels in glomus cells, which leads to depolarization, Ca2+ entry and release of transmitters that activate afferent nerve fibers. The molecular mechanisms underlying K+ channel modulation by O2 tension are unknown. Putative hypoxia-sensing mechanisms can be studied in detail using genetically modified mice in conjunction with a thin carotid body slice preparation. We discuss here the role in CB oxygen sensing of the hypoxia-inducible factor 1alpha, the mitochondrial complex II subunit D, and heme oxygenase 2. In chronic hypoxia the CB grows with increase in glomus cell number. We identified CB stem cells of glial lineage, which can differentiate into functionally normal glomus cells.
Authors:
José López-Barneo; Patricia Ortega-Sáenz; Ricardo Pardal; Alberto Pascual; José I Piruat; Rocío Durán; Raquel Gómez-Díaz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  1177     ISSN:  1749-6632     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-22     Completed Date:  2009-11-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  119-31     Citation Subset:  IM    
Affiliation:
Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, Spain. lbarneo@us.es
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MeSH Terms
Descriptor/Qualifier:
Animals
Anoxia / metabolism,  physiopathology
Carotid Body / metabolism*
Humans
Ion Channels / metabolism
Mice
Mice, Mutant Strains
Oxygen / metabolism*
Rats
Stem Cells / cytology,  metabolism
Chemical
Reg. No./Substance:
0/Ion Channels; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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