Document Detail

Oxygen saturation trends in preterm infants during the first 15 min after birth.
MedLine Citation:
PMID:  19890344     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine oxygen saturation (SpO(2)) trends in healthy preterm newborns during the first 15 min after birth and to ascertain factors affecting SpO(2) changes during that period. STUDY DESIGN: An observational study was conducted. Preterm newborns with gestational age (GA) less than 35 weeks, who did not require oxygen supplementation during the first 15 min of life, were enrolled. Pulse oximetry was applied to the right hand immediately after birth. SpO(2) data were recorded continuously every 2 s and were then transferred to a Microsoft Excel spreadsheet for analysis. The time to reach a stable SpO(2) >or=85 or >or=90% was described by the Kaplan-Meier method and compared using log-rank test. RESULT: A total of 102 preterm newborns were eligible, of whom 27 were excluded, resulting in 75 newborns enrolled into the study with a median (range) GA of 35 (29 to 35) weeks, median (range) birth weight of 2390 (1270 to 2990) g and median (range) Apgar scores at 1 and 5 min of 9 (5 to 10) and 10 (7 to 10), respectively. There was a gradual increase in SpO(2) with time. The median (interquartile range, IQR) SpO(2) at 2, 3, 4, 5 and 6 min was 77% (72 to 92), 84% (75 to 94), 88% (80 to 94), 90% (79 to 95) and 95% (85 to 97), respectively. Newborns with a lower GA seemed to have lower SpO(2) values. The median (IQR) time to reach a stable SpO(2) >or=85 or >or=90% was 4 (3 to 6) and 5 (3 to 57) min, respectively. The mode of delivery was a significant factor affecting SpO(2); infants delivered by cesarean section had a significantly lower SpO(2) and took a longer time to reach SpO(2) >or=85% compared with those delivered by vaginal delivery (HR=1.96, 95% CI=1.11 to 3.49; P=0.02). All enrolled newborns had no serious complications and they survived to discharge. CONCLUSION: SpO(2) in preterm newborns gradually increased with time. Approximately half of the preterm newborns had an SpO(2) <90% during the first 5 min of life. Infants delivered by cesarean section had a lower SpO(2) than those delivered by vaginal delivery.
P Nuntnarumit; K Rojnueangnit; A Tangnoo
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Publication Detail:
Type:  Journal Article     Date:  2009-11-05
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  30     ISSN:  1476-5543     ISO Abbreviation:  J Perinatol     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-28     Completed Date:  2010-09-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  399-402     Citation Subset:  IM    
Faculty of Medicine, Department of Pediatrics, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
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MeSH Terms
Apgar Score
Infant, Newborn
Infant, Premature / blood*
Kaplan-Meiers Estimate
Reference Values

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