Document Detail

Oxygen saturation of the low osmolar contrast media iohexol, ioxaglate and iodixanol. Effects on contractile force and frequency of ventricular fibrillation in the isolated rabbit heart.
MedLine Citation:
PMID:  2261303     Owner:  NLM     Status:  MEDLINE    
During coronary angiography the exchange of blood with a contrast medium solution causes a period of hypoxia. To investigate whether oxygen saturation of the contrast medium could be beneficial, low osmolar contrast media were infused without and with oxygen saturation into the coronary arteries of the isolated rabbit heart. Iohexol (150-300 mg I/ml, without NaCl or with 20-30 mM NaCl), iodixanol (320 mg I/ml, contains 24 mM NaCl) and ioxaglate (160 mg I/ml, contains 75 mM Na+) were infused without and with oxygen saturation. The decrease in contractile force (CF) of the heart, from the contrast medium solutions, was reduced when the solutions were saturated with oxygen. Oxygen saturation of iohexol (350 mg I/ml, without or with 10 mM NaCl) did not change the frequency of ventricular fibrillations (VF). Low osmolar contrast media, when saturated with oxygen, thus caused a reduced decrease in CF without changing the frequency of VF. This might be beneficial in clinical cardioangiography by reducing the adverse effects from the media.
L Bååth; T Almén; A Oksendal
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta radiologica (Stockholm, Sweden : 1987)     Volume:  31     ISSN:  0284-1851     ISO Abbreviation:  Acta Radiol     Publication Date:  1990 Sep 
Date Detail:
Created Date:  1991-02-05     Completed Date:  1991-02-05     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8706123     Medline TA:  Acta Radiol     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  519-23     Citation Subset:  IM    
Department of Diagnostic Radiology, Malmö Allmänna Sjukhus, University of Lund, Sweden.
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MeSH Terms
Anoxia / metabolism
Heart / radiography*
Iohexol / chemistry,  metabolism*
Ioxaglic Acid / chemistry,  metabolism*
Myocardial Contraction
Myocardium / metabolism*
Osmolar Concentration
Oxygen / metabolism*
Triiodobenzoic Acids / chemistry,  metabolism*
Ventricular Fibrillation / metabolism
Reg. No./Substance:
0/Triiodobenzoic Acids; 59017-64-0/Ioxaglic Acid; 66108-95-0/Iohexol; 7782-44-7/Oxygen; 92339-11-2/iodixanol

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