Document Detail

Oxygen saturation and hemoglobin A content in patients with sickle cell disease undergoing erythrocytapheresis.
MedLine Citation:
PMID:  12423535     Owner:  NLM     Status:  MEDLINE    
Severe hypoxia occurs in patients with acute chest syndrome, and erythrocytapheresis has been shown to improve oxygenation. Patients with sickle cell anemia also have decreased baseline oxygen saturation values, but the effect of erythrocytapheresis on steady-state oxygenation has not been well studied. We investigated the changes in oxygen saturation versus hematocrit, fraction of hemoglobin A, and transfusion volume during 71 prophylactic erythrocytapheresis procedures performed in 5 stable patients with sickle cell anemia. Each patient had a history of either acute chest syndrome or stroke, but no serious events occurred while enrolled in the chronic exchange program. The oxygen saturation improved from 1% to 6% during erythrocytapheresis in each of our patients (p < 0.001) regardless of preprocedure saturation level or total hematocrit. We have shown that decreased baseline oxygen saturation in sickle cell disease is related to abnormal hemoglobin S levels, and oxygen saturation can be improved with erythrocytapheresis, independent of any change in the total hematocrit.
Thomas P Nifong; Ronald E Domen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Therapeutic apheresis : official journal of the International Society for Apheresis and the Japanese Society for Apheresis     Volume:  6     ISSN:  1091-6660     ISO Abbreviation:  Ther Apher     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-11-08     Completed Date:  2003-01-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9706703     Medline TA:  Ther Apher     Country:  United States    
Other Details:
Languages:  eng     Pagination:  390-3     Citation Subset:  IM    
Department of Pathology, Penn State Milton S Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.
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MeSH Terms
Anemia, Sickle Cell / blood,  therapy*
Erythrocyte Transfusion*
Hemoglobin A / analysis*
Hemoglobin, Sickle / analysis
Oxygen / blood*
Reg. No./Substance:
0/Hemoglobin, Sickle; 7782-44-7/Oxygen; 9034-51-9/Hemoglobin A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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