| Oxygen regulates epithelial-to-mesenchymal transition: insights into molecular mechanisms and relevance to disease. | |
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MedLine Citation:
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PMID: 19536078 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Epithelial-to-mesenchymal transition (EMT) is a developmentally vital, molecularly complex cellular process by which epithelial cells lose apico-basal polarity and cell-cell contact, become motile, and acquire mesenchymal characteristics. Under pathophysiological conditions EMT has a central role in cancer progression and metastasis, and has been associated with fibrotic disorders. Microenvironmental changes such as alterations in oxygen levels and activation of hypoxic signaling through hypoxia-inducible factor (HIF) are emerging as important triggers and modulators of EMT. Recent insights into potential molecular mechanisms underlying oxygen-dependent regulation of this process and their relevance to disease are discussed. |
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Authors:
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Volker H Haase |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2009-06-17 |
Journal Detail:
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Title: Kidney international Volume: 76 ISSN: 1523-1755 ISO Abbreviation: Kidney Int. Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-14 Completed Date: 2009-10-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0323470 Medline TA: Kidney Int Country: United States |
Other Details:
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Languages: eng Pagination: 492-9 Citation Subset: IM |
Affiliation:
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Department of Medicine, Vanderbilt University Medical Center, C-3119A, MCN, 1161 21stAvenue, Nashville, TN 37232, USA. volker.haase@vanderbilt.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anoxia / metabolism Cell Communication Cell Polarity Chronic Disease Epithelial Cells / pathology* Humans Hypoxia-Inducible Factor 1, alpha Subunit / metabolism Kidney Diseases / pathology Mesoderm / pathology* Oxygen / pharmacology* Repressor Proteins / physiology Signal Transduction Twist Transcription Factor / physiology |
| Chemical | |
Reg. No./Substance:
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0/Hypoxia-Inducible Factor 1, alpha Subunit; 0/Repressor Proteins; 0/Twist Transcription Factor; 7782-44-7/Oxygen |
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