Document Detail


Oxygen regulates epithelial-to-mesenchymal transition: insights into molecular mechanisms and relevance to disease.
MedLine Citation:
PMID:  19536078     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Epithelial-to-mesenchymal transition (EMT) is a developmentally vital, molecularly complex cellular process by which epithelial cells lose apico-basal polarity and cell-cell contact, become motile, and acquire mesenchymal characteristics. Under pathophysiological conditions EMT has a central role in cancer progression and metastasis, and has been associated with fibrotic disorders. Microenvironmental changes such as alterations in oxygen levels and activation of hypoxic signaling through hypoxia-inducible factor (HIF) are emerging as important triggers and modulators of EMT. Recent insights into potential molecular mechanisms underlying oxygen-dependent regulation of this process and their relevance to disease are discussed.
Authors:
Volker H Haase
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2009-06-17
Journal Detail:
Title:  Kidney international     Volume:  76     ISSN:  1523-1755     ISO Abbreviation:  Kidney Int.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-14     Completed Date:  2009-10-22     Revised Date:  2013-06-24    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  United States    
Other Details:
Languages:  eng     Pagination:  492-9     Citation Subset:  IM    
Affiliation:
Department of Medicine, Vanderbilt University Medical Center, C-3119A, MCN, 1161 21stAvenue, Nashville, TN 37232, USA. volker.haase@vanderbilt.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Anoxia / metabolism
Cell Communication
Cell Polarity
Chronic Disease
Epithelial Cells / pathology*
Humans
Hypoxia-Inducible Factor 1, alpha Subunit / metabolism
Kidney Diseases / pathology
Mesoderm / pathology*
Oxygen / pharmacology*
Repressor Proteins / physiology
Signal Transduction
Twist Transcription Factor / physiology
Grant Support
ID/Acronym/Agency:
R01 DK080821/DK/NIDDK NIH HHS; R01 DK081646/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Hypoxia-Inducible Factor 1, alpha Subunit; 0/Repressor Proteins; 0/Twist Transcription Factor; 7782-44-7/Oxygen
Comments/Corrections

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