Document Detail

Oxygen pulse is not predictive of stroke volume in heart failure.
MedLine Citation:
PMID:  16823360     Owner:  NLM     Status:  MEDLINE    
AIM: Stroke volume (SV) is the major cardiovascular discriminator between those that are exercise trained versus untrained individuals and healthy individuals versus those with pathologic left ventricular dysfunction. Furthermore, since the increase in oxygen pulse (O(2)P) (O(2)P=VO(2)/HR?oxygen uptake/heart rate) that occurs with exercise is a function of SV and the arterial-venous oxygen difference (a-vO(2)), O(2)P has been demonstrated a reliable indicator of SV for healthy individuals. Although commonly used as a physiological and clinical marker of SV, the validity of O(2)P as an indicator of SV in patients with heart failure has not been investigated. METHODS: Thirty-one (23 men, 8 women) patients (age: 64+/-7.9; ejection fraction: 24+/-7.8) with chronic heart failure had cardiac output measured during steady-state workloads (25 watts and 75% VO(2peak)) upon entry and again at completion of 12 weeks of exercise training. Four patients were excluded due to clinical complications and 3 because of non-compliance; therefore, 24 patients completed the study. RESULTS: The relationships between SV and O2P are: 1) baseline: SV=11.1+4(O2P), SEE=11.8; r(2)=0.39 and 2) study completion: SV=25.1+2.3(O2P), SEE=12.7; r(2)=0.21. While SV did not increase after 25 watts, O2P continued to increase by 17%, respectively. In addition, there were no training effects on SV or O(2)P. As SV increased, O(2)P underpredicted measured SV. CONCLUSIONS: In patients with heart failure and poor left ventricular function, O(2)P is not recommended as a marker of the SV during exercise.
T R McConnell; W M Shearn; T A Klinger; K Strohecker
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of sports medicine and physical fitness     Volume:  46     ISSN:  0022-4707     ISO Abbreviation:  J Sports Med Phys Fitness     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-07-06     Completed Date:  2006-12-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376337     Medline TA:  J Sports Med Phys Fitness     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  286-92     Citation Subset:  IM    
Department of Exercise Science and Athletics, Bloomsburg University, PA 17815, USA.
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MeSH Terms
Blood Pressure / physiology
Body Weight
Cardiac Output / physiology
Cardiac Output, Low / physiopathology*,  rehabilitation
Chronic Disease
Exercise Test
Exercise Therapy
Heart Rate / physiology*
Middle Aged
Oxygen Consumption / physiology*
Stroke Volume / physiology*
Weight Lifting

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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