| Oxygen pulse is not predictive of stroke volume in heart failure. | |
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MedLine Citation:
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PMID: 16823360 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: Stroke volume (SV) is the major cardiovascular discriminator between those that are exercise trained versus untrained individuals and healthy individuals versus those with pathologic left ventricular dysfunction. Furthermore, since the increase in oxygen pulse (O(2)P) (O(2)P=VO(2)/HR?oxygen uptake/heart rate) that occurs with exercise is a function of SV and the arterial-venous oxygen difference (a-vO(2)), O(2)P has been demonstrated a reliable indicator of SV for healthy individuals. Although commonly used as a physiological and clinical marker of SV, the validity of O(2)P as an indicator of SV in patients with heart failure has not been investigated. METHODS: Thirty-one (23 men, 8 women) patients (age: 64+/-7.9; ejection fraction: 24+/-7.8) with chronic heart failure had cardiac output measured during steady-state workloads (25 watts and 75% VO(2peak)) upon entry and again at completion of 12 weeks of exercise training. Four patients were excluded due to clinical complications and 3 because of non-compliance; therefore, 24 patients completed the study. RESULTS: The relationships between SV and O2P are: 1) baseline: SV=11.1+4(O2P), SEE=11.8; r(2)=0.39 and 2) study completion: SV=25.1+2.3(O2P), SEE=12.7; r(2)=0.21. While SV did not increase after 25 watts, O2P continued to increase by 17%, respectively. In addition, there were no training effects on SV or O(2)P. As SV increased, O(2)P underpredicted measured SV. CONCLUSIONS: In patients with heart failure and poor left ventricular function, O(2)P is not recommended as a marker of the SV during exercise. |
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Authors:
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T R McConnell; W M Shearn; T A Klinger; K Strohecker |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of sports medicine and physical fitness Volume: 46 ISSN: 0022-4707 ISO Abbreviation: J Sports Med Phys Fitness Publication Date: 2006 Jun |
Date Detail:
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Created Date: 2006-07-06 Completed Date: 2006-12-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376337 Medline TA: J Sports Med Phys Fitness Country: Italy |
Other Details:
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Languages: eng Pagination: 286-92 Citation Subset: IM |
Affiliation:
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Department of Exercise Science and Athletics, Bloomsburg University, PA 17815, USA. tmcconne@bloomu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Pressure
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physiology Body Weight Cardiac Output / physiology Cardiac Output, Low / physiopathology*, rehabilitation Chronic Disease Electrocardiography Exercise Test Exercise Therapy Female Forecasting Heart Rate / physiology* Humans Male Middle Aged Oxygen Consumption / physiology* Spirometry Stroke Volume / physiology* Weight Lifting |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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