Document Detail


Oxygen pressure distribution in the heart in vivo and evaluation of the ischemic "border zone".
MedLine Citation:
PMID:  8184947     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Quantitation of the oxygen pressure distribution in the heart provides an accurate definition of metabolically viable cells adjacent to ischemic injury. By injection of a phosphorescent oxygen probe into the blood of newborn piglets and illumination of the heart with monochromatic light, a series of images of the heart were collected with use of a gated intensified CCD camera. These sets of images were used to calculate two-dimensional maps of the oxygen pressure in the epicardial microvasculature. Occlusion of a distal arterial vessel resulted in a hypoxic area containing a central focus of near-zero oxygen pressure bordered by tissue with diminished but nonzero oxygen pressures. These border zones extended for several millimeters from the hypoxic core, with the oxygen pressures progressively increasing from the focus to the normoxic region. The maps of oxygen distribution obtained by phosphorescence imaging provide rapid and quantitative measure of the oxygen pressures in the beating heart in vivo. They accurately show the degree of oxygen deprivation and the extent of an ischemic border zone that may respond to treatment.
Authors:
W L Rumsey; M Pawlowski; N Lejavardi; D F Wilson
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  266     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1994 Apr 
Date Detail:
Created Date:  1994-06-10     Completed Date:  1994-06-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H1676-80     Citation Subset:  IM    
Affiliation:
Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia 19104.
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MeSH Terms
Descriptor/Qualifier:
Animals
Luminescent Measurements
Myocardial Ischemia / metabolism*
Myocardium / metabolism*
Optics and Photonics
Oxygen / metabolism*
Partial Pressure
Swine
Tissue Distribution
Grant Support
ID/Acronym/Agency:
NS-10939/NS/NINDS NIH HHS; NS-34165/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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