Document Detail


Oxygen, oxidative stress, hypoxia, and heart failure.
MedLine Citation:
PMID:  15765131     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A constant supply of oxygen is indispensable for cardiac viability and function. However, the role of oxygen and oxygen-associated processes in the heart is complex, and they and can be either beneficial or contribute to cardiac dysfunction and death. As oxygen is a major determinant of cardiac gene expression, and a critical participant in the formation of ROS and numerous other cellular processes, consideration of its role in the heart is essential in understanding the pathogenesis of cardiac dysfunction.
Authors:
Frank J Giordano
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  115     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-03-14     Completed Date:  2005-05-09     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  500-8     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA. Frank.Giordano@yale.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Anoxia / metabolism*
Calcium / metabolism
Cardiac Output, Low / pathology,  physiopathology*
Energy Metabolism
Gene Expression Regulation
Humans
Hypertrophy
Ion Channels / metabolism
Lipids / toxicity
Mitochondria / metabolism
Myocardial Ischemia / metabolism
Myocardium / cytology,  metabolism,  pathology
Oxidative Stress*
Oxygen / metabolism*
Reactive Oxygen Species / metabolism
Signal Transduction / physiology
Chemical
Reg. No./Substance:
0/Ion Channels; 0/Lipids; 0/Reactive Oxygen Species; 7440-70-2/Calcium; 7782-44-7/Oxygen
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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