| Oxygen modulates the growth of skin fibroblasts. | |
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MedLine Citation:
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PMID: 12418928 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Elevated oxygen tensions are inhibitory to the growth of skin fibroblasts. Skin fibroblasts grow better at oxygen tensions below 137 mm Hg regardless of seeding density. A wide range of oxygen tensions, including those in the physiological range, strongly modulate the growth of human skin fibroblasts. There were no significant differences between the responses of fetal and postnatal cell lines to changes in ambient oxygen tension. In all cases, higher oxygen tensions significantly impeded cell growth. Seeding cells at 10(4) cells/cm(2) afforded some protection from the deleterious effects of hyperoxia. Oxygen tensions exceeding the amount present in ambient room air also impeded cell growth at this higher seeding density, but the effect did not become significant until the oxygen partial pressure reached 241 mm Hg. At lower oxygen tensions, cells seeded at 10(3) cells/cm(2) grew more rapidly than did cells seeded at 10(4) cells/cm(2). These findings may have implications for the treatment of poorly healing wounds with hyperbaric oxygen. |
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Authors:
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Arthur K Balin; Loretta Pratt |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: In vitro cellular & developmental biology. Animal Volume: 38 ISSN: 1071-2690 ISO Abbreviation: In Vitro Cell. Dev. Biol. Anim. Publication Date: 2002 May |
Date Detail:
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Created Date: 2002-11-06 Completed Date: 2003-07-07 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9418515 Medline TA: In Vitro Cell Dev Biol Anim Country: United States |
Other Details:
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Languages: eng Pagination: 305-10 Citation Subset: IM |
Affiliation:
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Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York 10021, USA. akbalin@aol.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Cell Division* Cell Line Culture Media Female Fetus Fibroblasts / cytology*, metabolism Gestational Age Humans Infant Infant, Newborn Male Middle Aged Oxygen / metabolism* Pregnancy Skin / cytology*, metabolism Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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AG00282/AG/NIA NIH HHS; AG04993/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Culture Media; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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