Document Detail

Oxygen metabolism changes in patients with idiopathic normal pressure hydrocephalus before and after shunting operation.
MedLine Citation:
PMID:  17714325     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The present study revealed the changes in cerebral oxygen metabolism before and after ventriculo-peritoneal shunt (VPS) using (15)O positron emission tomography ((15)O-PET). METHODS: Eight patients with idiopathic normal pressure hydrocephalus (i-NPH) underwent VPS. A (15)O-PET study was undertaken before and approximately 3 months after VPS. In five patients, the symptoms improved based on the classification by Krauss et al. [Neurosurgery 1996;39:292] (good responders) after VPS. In three patients, the symptoms improved subjectively following VPS (poor responders). The changes in oxygen metabolism before and after VPS were analyzed. RESULTS: The postoperative regional cerebral metabolic rate of oxygen (rCMRO(2)) of the good responders increased significantly. The postoperative regional oxygen extraction fraction (rOEF) is reduced in the poor responders. CONCLUSION: The improvement of rCMRO(2) correlated with the response to VPS. Significant changes in rOEF might predict poor response to VPS.
J Miyamoto; K Tatsuzawa; Y Inoue; Y Imahori; K Mineura
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  116     ISSN:  0001-6314     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-23     Completed Date:  2007-11-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  137-43     Citation Subset:  IM    
Department of Neurosurgery, Kyoto Prefectural University of Medicine, Kamigyoku, Kyoto, Japan.
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MeSH Terms
Blood Volume / physiology
Brain / metabolism*,  radionuclide imaging
Cerebrovascular Circulation / physiology
Follow-Up Studies
Hydrocephalus, Normal Pressure / metabolism*,  radionuclide imaging,  surgery*
Oxygen Consumption / physiology*
Positron-Emission Tomography
Treatment Outcome
Ventriculoperitoneal Shunt*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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