Document Detail

Oxygen kinetics in the vitreous substitute perfluorotributylamine: a 19F NMR study in vivo.
MedLine Citation:
PMID:  2071349     Owner:  NLM     Status:  MEDLINE    
Perfluorocarbon (PFC) vitreous substitutes yielded promising results in the surgical management of retinal detachments. This success is due primarily to their physical properties. However, oxygen kinetics in PFC in vivo have not been investigated. The oxygen flux in the vitreous substitute perfluorotributylamine (FTBA) was assessed in the rabbit eye by monitoring the partial oxygen pressure (PO2) in real-time using Fluorine-19 nuclear magnetic resonance spectroscopy (19F NMR) The spin-lattice relaxation rate (T1)-1 of the CF3 resonance of FTBA is a rapid and sensitive index of PO2. T1-derived PO2 from the FTBA-filled rabbit eye was followed at regular time intervals under different oxygenation protocols. In the first series of experiments, FTBA in the vitreous space was oxygenated by ventilating the rabbit with a mixture of 95% O2 and 5% CO2. The oxygen uptake profile could be approximated by a simple exponential function with a time constant of 159 +/- 110 min (mean +/- SD, n = 3). A more reproducible correlate was obtained by performing an initial rate analysis on the first hour of ventilation with high oxygen levels. This analysis showed that the rate of increase in FTBA PO2 was 2.34 +/- 0.67 mm Hg/min (mean +/- SD, r2 = 0.99, n = 7). After the animal was removed from the 95% O2/5% CO2 gas and was ventilated with room air, the oxygen clearance profile could be approximated in all cases by a single exponential with a time constant of 59.8 +/- 9.6 min (mean +/- SD, n = 4).(ABSTRACT TRUNCATED AT 250 WORDS)
B A Berkowitz; C A Wilson; D L Hatchell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  32     ISSN:  0146-0404     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  1991 Jul 
Date Detail:
Created Date:  1991-08-21     Completed Date:  1991-08-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2382-7     Citation Subset:  IM    
National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709.
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MeSH Terms
Magnetic Resonance Spectroscopy*
Oxygen / metabolism*,  physiology
Vitreous Body / metabolism*
Grant Support
Reg. No./Substance:
0/Fluorocarbons; 311-89-7/perfluorotributylamine; 7782-41-4/Fluorine; 7782-44-7/Oxygen

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