Document Detail


Oxygen-induced retinopathy in the newborn rat: a scoring system for the evaluation of retinal vascular changes. Scoring system for OIR in the rat.
MedLine Citation:
PMID:  2103526     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The authors describe a scoring system they have developed for evaluating damage produced in the retinal vascular network of the newborn rat by exposure to oxygen. India ink-injected retinal flat mounts are used. The scoring system provides for division of the retina into three concentric zones with the optic disk as a center point. Each retinal quadrant is then examined for the presence of the following lesions of progressive severity: vaso-obliteration of the capillary network, loss of the periarteriolar capillary-free zone, newly formed capillary tufts. When more than one type of lesion is present in a quadrant, only the most severe lesion is considered. The numerical score corresponding to that lesion is then multiplied by the factor corresponding to the concentric zone in which the lesion lies to give the quadrant score. The total retinal score is represented by the sum of the four quadrant scores. This type of system, if adopted by other investigators, can facilitate precise and systematic description of the results of different experimental protocols.
Authors:
B Ricci; D Lepore; E Zonghi; G Calogero
Related Documents :
2924176 - Fibromatosis of the brachial plexus and shoulder girdle.
11911036 - Neonatal choroid plexus cysts and early childhood developmental outcome.
23119556 - Adenomatoid odontogenic tumour of the maxillary sinus.
614516 - Disseminated prothothecosis in a dog.
19453706 - Cerebral lesions can impair fmri-based language lateralization.
7727636 - Suppurative cutaneous granulomata caused by microascus cinereus in a patient with chron...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Documenta ophthalmologica. Advances in ophthalmology     Volume:  76     ISSN:  0012-4486     ISO Abbreviation:  Doc Ophthalmol     Publication Date:    1990-1991
Date Detail:
Created Date:  1991-10-08     Completed Date:  1991-10-08     Revised Date:  2006-07-19    
Medline Journal Info:
Nlm Unique ID:  0370667     Medline TA:  Doc Ophthalmol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  241-9     Citation Subset:  IM; S    
Affiliation:
Department of Ophthalmology, Catholic University, Rome, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Disease Models, Animal
Oxygen / toxicity*
Rats
Rats, Inbred Strains
Reference Values
Retina / drug effects,  pathology*
Retinal Diseases / chemically induced*,  pathology
Retinal Vessels / drug effects,  pathology*
Chemical
Reg. No./Substance:
7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A long term follow up of ocular siderosis: quantitative assessment of the electroretinogram.
Next Document:  Changes in macular function throughout adulthood.