Document Detail

Oxygen free radicals and the systemic inflammatory response.
MedLine Citation:
PMID:  15230345     Owner:  NLM     Status:  MEDLINE    
The generation of oxygen free radicals is known to be involved in the development of the systemic inflammatory response syndrome. In addition to their actions as noxious mediators generated by inflammatory cells, these molecules play also a crucial role contributing to the onset and progression of inflammation in distant organs. In the early stages of the process, free radicals exert their actions via activation of nuclear factors, as NFkappaB or AP-1, that induce the synthesis of cytokines. In later stages, endothelial cells are activated due to the synergy between free radicals and cytokines, promoting the synthesis of inflammatory mediators and adhesion molecules. Finally, free radicals exert their toxic effects at the site of inflammation by reacting with different cell components, inducing loss of function and cell death. This review focuses on progress in the understanding the different actions of free radicals at the sequential stages of the development of the systemic inflammatory response.
Daniel Closa; Emma Folch-Puy
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  IUBMB life     Volume:  56     ISSN:  1521-6543     ISO Abbreviation:  IUBMB Life     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-07-02     Completed Date:  2005-01-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100888706     Medline TA:  IUBMB Life     Country:  England    
Other Details:
Languages:  eng     Pagination:  185-91     Citation Subset:  IM    
Department of Experimental Pathology, IIBB-CSIC-IDIBAPS, Barcelona, Spain.
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MeSH Terms
Antioxidants / therapeutic use
Cytokines / biosynthesis
Endothelial Cells / metabolism
Models, Biological*
Reactive Oxygen Species / metabolism*
Signal Transduction / physiology*
Systemic Inflammatory Response Syndrome / metabolism*,  therapy
Reg. No./Substance:
0/Antioxidants; 0/Cytokines; 0/Reactive Oxygen Species

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