| Oxygen free radicals and myocardial reperfusion injury. | |
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MedLine Citation:
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PMID: 3276245 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Diseases involving tissue reperfusion following ischemia are gaining significance in emergency medicine. The significance of reperfusion injury and the probable role of oxygen-derived free radicals has been described in many tissues, particularly the heart. During myocardial reperfusion a burst of oxygen-derived free radicals overwhelms normal cellular defenses. These radicals may have several detrimental effects. They can oxidize lipids, leading to membrane dysfunction. They can also alter nucleic and other proteins. Cellular dysfunction and death may ensue. Prevention of oxygen-derived free radical injury appears possible and may be feasible for several disease processes, including myocardial reperfusion after infarction. |
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Authors:
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R C Dart; A B Sanders |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Annals of emergency medicine Volume: 17 ISSN: 0196-0644 ISO Abbreviation: Ann Emerg Med Publication Date: 1988 Jan |
Date Detail:
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Created Date: 1988-02-09 Completed Date: 1988-02-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8002646 Medline TA: Ann Emerg Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 53-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Surgery, University of Arizona College of Medicine, Tucson. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Coronary Disease / drug therapy, metabolism Emergencies* Free Radicals Heart / drug effects Humans Lipid Peroxides / metabolism Myocardial Infarction / drug therapy* Myocardium / metabolism* Oxygen / adverse effects*, pharmacology Perfusion |
| Chemical | |
Reg. No./Substance:
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0/Free Radicals; 0/Lipid Peroxides; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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