Document Detail

Oxygen free radicals and myocardial reperfusion injury.
MedLine Citation:
PMID:  3276245     Owner:  NLM     Status:  MEDLINE    
Diseases involving tissue reperfusion following ischemia are gaining significance in emergency medicine. The significance of reperfusion injury and the probable role of oxygen-derived free radicals has been described in many tissues, particularly the heart. During myocardial reperfusion a burst of oxygen-derived free radicals overwhelms normal cellular defenses. These radicals may have several detrimental effects. They can oxidize lipids, leading to membrane dysfunction. They can also alter nucleic and other proteins. Cellular dysfunction and death may ensue. Prevention of oxygen-derived free radical injury appears possible and may be feasible for several disease processes, including myocardial reperfusion after infarction.
R C Dart; A B Sanders
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Annals of emergency medicine     Volume:  17     ISSN:  0196-0644     ISO Abbreviation:  Ann Emerg Med     Publication Date:  1988 Jan 
Date Detail:
Created Date:  1988-02-09     Completed Date:  1988-02-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8002646     Medline TA:  Ann Emerg Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  53-8     Citation Subset:  AIM; IM    
Department of Surgery, University of Arizona College of Medicine, Tucson.
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MeSH Terms
Coronary Disease / drug therapy,  metabolism
Free Radicals
Heart / drug effects
Lipid Peroxides / metabolism
Myocardial Infarction / drug therapy*
Myocardium / metabolism*
Oxygen / adverse effects*,  pharmacology
Reg. No./Substance:
0/Free Radicals; 0/Lipid Peroxides; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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