Document Detail


Oxygen free radicals and corneal endothelium.
MedLine Citation:
PMID:  2562169     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have demonstrated that corneal endothelial cells are susceptible to damage from hydrogen peroxide. Hydrogen peroxide perfusion of corneal endothelium results in physiologic and anatomic disruption of corneal endothelial cells with resulting swelling of the corneal stroma. Enzymatically generated superoxide anion produced endothelial damage which could not be blocked with superoxide dismutase (which removes superoxide anion from the system), but could it be blocked with catalase which removes hydrogen peroxide from the system. This indicated that the superoxide anion was not the toxic agent, but rather hydrogen peroxide, its dismutation product. Enzymatically generated oxygen free radical in the anterior chamber of the rabbit eye resulted in an increased iris vascular permeability which persisted for up to 24 hours following anterior chamber injection of hypoxanthine and xanthine oxidase. Young animals were better able to withstand oxidative stress to the eye then were older animals. The physiologic effects of oxidative stress in young animals can be made comparable to that in the older animals by depletion of catalase with 3-aminotriazole.
Authors:
D S Hull; K Green
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Lens and eye toxicity research     Volume:  6     ISSN:  1042-6922     ISO Abbreviation:  Lens Eye Toxic Res     Publication Date:  1989  
Date Detail:
Created Date:  1991-04-18     Completed Date:  1991-04-18     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8916639     Medline TA:  Lens Eye Toxic Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  87-91     Citation Subset:  IM    
Affiliation:
Department of Ophthalmology, Medical College of Georgia, Augusta 30912.
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MeSH Terms
Descriptor/Qualifier:
Aging / metabolism
Animals
Anterior Chamber / metabolism
Endothelium, Corneal / metabolism*
Eye Diseases / metabolism
Free Radicals
Hydrogen Peroxide / metabolism
Inflammation / metabolism
Iris / metabolism
Superoxide Dismutase / metabolism
Superoxides / metabolism*
Chemical
Reg. No./Substance:
0/Free Radicals; 11062-77-4/Superoxides; 7722-84-1/Hydrogen Peroxide; EC 1.15.1.1/Superoxide Dismutase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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