Document Detail

Oxygen-derived free radicals mediate the cutaneous necrotizing vasculitis induced by epinephrine in endotoxin-primed rabbits.
MedLine Citation:
PMID:  2182724     Owner:  NLM     Status:  MEDLINE    
To assess the possible role of oxygen-derived free radical in the pathogenesis of cutaneous necrotizing vasculitis (Thomas reaction) induced by epinephrine in endotoxin-primed rabbits, animals were treated with superoxide dismutase (intraperitoneal or local), catalase, allopurinol, or ibuprofen 2 h before inducing the reaction. This is done by an earlobe intravenous injection (10 micrograms) of endotoxin followed by an intradermal injection (100 micrograms) of epinephrine in the shaved abdomen; 18-24 h later, a hemorrhagic-necrotic lesion can be observed at the site of the epinephrine injection. The reaction was completely inhibited by superoxide dismutase, catalase, and ibuprofen, while allopurinol afforded only partial protection. Thus, oxyradicals seem to participate in the pathogenesis of this reaction.
P H Ward; M Maldonado; M Moreno; B Günther; E Vivaldi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  161     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-05-24     Completed Date:  1990-05-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1020-2     Citation Subset:  AIM; IM    
Departamento de Ciencias Fisiológicas, Universidad de Concepción, Chile.
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MeSH Terms
Catalase / pharmacology
Endotoxins / toxicity*
Epinephrine / toxicity*
Escherichia coli*
Free Radicals
Lipopolysaccharides / toxicity
Oxygen / metabolism*
Skin / pathology
Superoxide Dismutase / pharmacology
Vasculitis / etiology*
Reg. No./Substance:
0/Endotoxins; 0/Free Radicals; 0/Lipopolysaccharides; 51-43-4/Epinephrine; 67924-63-4/endotoxin, Escherichia coli; 7782-44-7/Oxygen; EC; EC Dismutase

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