Document Detail


Oxygen-derived free radical generating capacity of polymorphonuclear cells in patients with ulcerative colitis.
MedLine Citation:
PMID:  2628137     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Oxygen-derived free radical generating capacity of polymorphonuclear cells in 27 patients with ulcerative colitis, 10 with acute bacterial diarrhea and 20 healthy volunteers, was measured by the luminol-dependent chemiluminescence method by stimulation of formyl-methionyl-leucyl-phenylalanine. Oxidative free radical generating capacity of polymorphonuclear cells in patients with active ulcerative colitis was markedly enhanced as compared with control (p less than 0.01), while this enhanced free radical production by the cells was not detected at remission stage. Serial analyses revealed that oxidative free radical production by the cells in patients with ulcerative colitis was markedly enhanced with clinical deterioration of the disease, but it returned to normal level with an improvement of clinical features. These results suggest that the increased oxidative free radical production by polymorphonuclear cells could be related to the pathogenesis or aggravation of ulcerative colitis.
Authors:
Y Shiratora; S Aoki; H Takada; H Kiriyama; K Ohto; K Hai; H Teraoka; S Matano; K Matsumoto; K Kamii
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Digestion     Volume:  44     ISSN:  0012-2823     ISO Abbreviation:  Digestion     Publication Date:  1989  
Date Detail:
Created Date:  1990-04-26     Completed Date:  1990-04-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0150472     Medline TA:  Digestion     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  163-71     Citation Subset:  IM    
Affiliation:
Division of Gastroenterology, Koshigaya Hospital, Dokkyo University School of Medicine, Saitama, Japan.
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MeSH Terms
Descriptor/Qualifier:
Colitis, Ulcerative / metabolism*,  pathology
Endotoxins / blood
Follow-Up Studies
Humans
Neutrophils / metabolism*
Oxygen / metabolism*
Superoxide Dismutase / metabolism*
Chemical
Reg. No./Substance:
0/Endotoxins; 7782-44-7/Oxygen; EC 1.15.1.1/Superoxide Dismutase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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