| Oxygen-dependent delayed fluorescence measured in skin after topical application of 5-aminolevulinic acid. | |
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MedLine Citation:
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PMID: 21770036 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Mitochondrial oxygen tension can be measured in vivo by means of oxygen-dependent quenching of delayed fluorescence of protoporphyrin IX (PpIX). Here we demonstrate that delayed fluorescence is readily observed from skin in rat and man after topical application of the PpIX precursor 5-aminolevulinic acid (ALA). Delayed fluorescence lifetimes respond to changes in inspired oxygen fraction and blood supply. The signals contain lifetime distributions and the fitting of rectangular distributions to the data appears more adequate than mono-exponential fitting. The use of topically applied ALA for delayed fluorescence lifetime measurements might pave the way for clinical use of this technique. (© 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim). |
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Authors:
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Floor A Harms; Wadim M I de Boon; Gianmarco M Balestra; Sander I A Bodmer; Tanja Johannes; Robert J Stolker; Egbert G Mik |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-19 |
Journal Detail:
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Title: Journal of biophotonics Volume: - ISSN: 1864-0648 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-7-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101318567 Medline TA: J Biophotonics Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
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Department of Anesthesiology, Laboratory of Experimental Anesthesiology, ErasmusMC, University Medical Center Rotterdam, Rotterdam, The Netherlands. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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